Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew | |
Xu, Ling1; Yu, Dandan1; Fan, Yu1; Peng, Li1; Wu, Yong1,2; Yao, Yong-Gang1,2,3 | |
刊名 | Proceedings of the national academy of sciences of the united states of america |
2016-09-27 | |
卷号 | 113期号:39页码:10950-10955 |
关键词 | Rig-i Mda5 Tree shrew Positive selection Functional replacement |
ISSN号 | 0027-8424 |
DOI | 10.1073/pnas.1604939113 |
通讯作者 | Yao, yong-gang(yaoyg@mail.kiz.ac.cn) |
英文摘要 | The function of the rig-i-like receptors (rlrs; including rig-i, mda5, and lgp2) as key cytoplasmic sensors of viral pathogen-associated molecular patterns (pamps) has been subjected to numerous pathogenic challenges and has undergone a dynamic evolution. we found evolutionary evidence that rig-i was lost in the chinese tree shrew lineage. along with the loss of rig-i, both mda5 (tmda5) and lgp2 (tlgp2) have undergone strong positive selection in the tree shrew. tmda5 or tmda5/tlgp2 could sense sendai virus (an rna virus posed as a rig-i agonist) for inducing type i ifn, although conventional rig-i and mda5 were thought to recognize distinct rna structures and viruses. tmda5 interacted with adaptor tmita (stingtmem173/eris), which was reported to bind only with rig-i. the positively selected sites in tmda5 endowed the substitute function for the lost rig-i. these findings provided insights into the adaptation and functional diversity of innate antiviral activity in vertebrates. |
WOS关键词 | INNATE IMMUNE-SYSTEM ; AMINO-ACID SITES ; RNA HELICASE ; ANTIVIRAL RESPONSES ; SIGNAL-TRANSDUCTION ; POSITIVE SELECTION ; LGP2 ; RECOGNITION ; ACTIVATION ; RECEPTORS |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
语种 | 英语 |
出版者 | NATL ACAD SCIENCES |
WOS记录号 | WOS:000383954700053 |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/2375876 |
专题 | 中国科学院大学 |
通讯作者 | Yao, Yong-Gang |
作者单位 | 1.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Kunming 650223, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Ling,Yu, Dandan,Fan, Yu,et al. Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew[J]. Proceedings of the national academy of sciences of the united states of america,2016,113(39):10950-10955. |
APA | Xu, Ling,Yu, Dandan,Fan, Yu,Peng, Li,Wu, Yong,&Yao, Yong-Gang.(2016).Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew.Proceedings of the national academy of sciences of the united states of america,113(39),10950-10955. |
MLA | Xu, Ling,et al."Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew".Proceedings of the national academy of sciences of the united states of america 113.39(2016):10950-10955. |
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