| A cgifnlp receptor from crassostrea gigas and its activation of the related genes in human jak/stat signaling pathway | |
| Zhang, Ran1,4; Liu, Rui1; Xin, Lusheng1,3; Chen, Hao1,3; Li, Chenghua4; Wang, Lingling2; Song, Linsheng2 | |
| 刊名 | Developmental and comparative immunology
 |
| 2016-12-01 | |
| 卷号 | 65页码:98-106 |
| 关键词 | Crassostrea gigas Interferon Interferon receptor Poly (i: c) Interferon stimulated genes |
| ISSN号 | 0145-305X |
| DOI | 10.1016/j.dci.2016.06.010 |
| 通讯作者 | Song, linsheng(lshsong@qdio.ac.cn) |
| 英文摘要 | Interferon is a highly pleiotropic cytokine, once binding to its receptors, can activate jak kinases and stat transcription factors to initiate the transcription of genes downstream from interferon-stimulated response elements. in the present study, a cytokine receptor-like 3 molecule was selected and cloned from oyster crassostrea gigas, which contained a fibronectin type iii domain (designed cgifnr-3). the expression pattern of cgifnr-3 mrna was detected in all the tested tissues including mantle, gills, hepatopancreas, muscle, and hemocytes, with the highest expression level in hemocytes. after poly (i: c) stimulation, the expression level of cgifnr-3 in hemocytes was observed to significantly increase at 3 h (13.06-fold, p < 0.01). cgifnr-3 was indicated to interact with cgifnlp by in vitro gst pull-down assay, and to activate the expression of transcription factors including isre, stat3 and gas, in human janus kinase signal transducer and activator of transcription (jak/stat) pathway after co-transfection in hek-293t cells in the reporter luciferase activity assay. these results suggested that cgifnr-3 could bind to cgifnlp as an interferon receptor and participate in the activation of jak/stat pathway in human, which will benefit for intensive studies of interferon signaling pathway in mollusc. (c) 2016 elsevier ltd. all rights reserved. |
| WOS关键词 | INTERFERON-GAMMA RECEPTOR ; JAK-STAT PATHWAY ; I INTERFERONS ; MOLECULAR CHARACTERIZATION ; GENOMIC ORGANIZATION ; IMMUNE-RESPONSES ; VIRUS-INFECTION ; HUMAN-CELLS ; IFN-GAMMA ; DROSOPHILA |
| WOS研究方向 | Immunology ; Zoology |
| WOS类目 | Immunology ; Zoology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000384388400011 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375865 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Song, Linsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Dalian Ocean Univ, Minist Agr, Key Lab Mariculture & Stock Enhancement North Chi, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ran,Liu, Rui,Xin, Lusheng,et al. A cgifnlp receptor from crassostrea gigas and its activation of the related genes in human jak/stat signaling pathway[J]. Developmental and comparative immunology,2016,65:98-106. |
| APA | Zhang, Ran.,Liu, Rui.,Xin, Lusheng.,Chen, Hao.,Li, Chenghua.,...&Song, Linsheng.(2016).A cgifnlp receptor from crassostrea gigas and its activation of the related genes in human jak/stat signaling pathway.Developmental and comparative immunology,65,98-106. |
| MLA | Zhang, Ran,et al."A cgifnlp receptor from crassostrea gigas and its activation of the related genes in human jak/stat signaling pathway".Developmental and comparative immunology 65(2016):98-106. |
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