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	Interferon regulatory factor 3-cl, an isoform of irf3, antagonizes activity of irf3
	Li, Chunhua1,2,3; Ma, Lixin2; Chen, Xinwen1
刊名	Cellular & molecular immunology
	2011
卷号	8期号:1页码:67-74
关键词	Interferon regulatory factor 3 Negative regulation Splicing variant
ISSN号	1672-7681
DOI	10.1038/cmi.2010.55
通讯作者	Chen, xinwen(chenxw@pentium.whiov.ac.cn)
英文摘要	Interferon regulatory factor 3 (irf3), one member of the irf family, plays a central role in induction of type i interferon (ifn) and regulation of apoptosis. controlled activity of irf3 is essential for its functions. during reverse transcription (rt)-pcr to clone the full-length open reading frame (orf) of irf3, we cloned a full-length orf encoding an isoform of irf3, termed as irf3-cl, and has a unique carboxyl-terminus of 125 amino acids. irf3-cl is ubiquitously expressed in distinct cell lines. overexpression of irf3-cl inhibits sendai virus (sev)-triggered induction of ifn-beta and sev-induced and inhibitor of nf-kappa b kinase-epsilon (ikk epsilon)-mediated nuclear translocation of irf3. when ikk epsilon is overexpressed, irf3-cl is associated with irf3. these results suggest that irf3-cl, the alternative splicing isoform of irf-3, may function as a negative regulator of irf3. cellular & molecular immunology (2011) 8, 67-74; doi:10.1038/cmi.2010.55; published online 6 december 2010
WOS关键词	INNATE ANTIVIRAL RESPONSE ; DOUBLE-STRANDED-RNA ; NF-KAPPA-B ; TRANSCRIPTION FACTORS ; FACTOR (IRF)-3 ; ACTIVATION ; LOCALIZATION ; INDUCTION ; INFECTION ; PATHWAYS
WOS研究方向	Immunology
WOS类目	Immunology
语种	英语
出版者	CHIN SOCIETY IMMUNOLOGY
WOS记录号	WOS:000285871400009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375856
专题	武汉病毒研究所
通讯作者	Chen, Xinwen
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Hubei Univ, Inst Biochem & Mol Biol, Wuhan 430062, Peoples R China 3.Chinese Acad Sci, Grad Sch, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Li, Chunhua,Ma, Lixin,Chen, Xinwen. Interferon regulatory factor 3-cl, an isoform of irf3, antagonizes activity of irf3[J]. Cellular & molecular immunology,2011,8(1):67-74.
APA	Li, Chunhua,Ma, Lixin,&Chen, Xinwen.(2011).Interferon regulatory factor 3-cl, an isoform of irf3, antagonizes activity of irf3.Cellular & molecular immunology,8(1),67-74.
MLA	Li, Chunhua,et al."Interferon regulatory factor 3-cl, an isoform of irf3, antagonizes activity of irf3".Cellular & molecular immunology 8.1(2011):67-74.

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