| Complex positive selection pressures drive the evolution of hiv-1 with different co-receptor tropisms | |
| Zhang ChiYu1; Ding Na1; Chen KePing1; Yang RongGe2 | |
| 刊名 | Science china-life sciences
 |
| 2010-10-01 | |
| 卷号 | 53期号:10页码:1204-1214 |
| 关键词 | Hiv-1 co-receptor tropism Adaptive evolution Positively selected site R5 and x4 Gp120 Epitopes |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-010-4066-5 |
| 通讯作者 | Zhang chiyu(zhangcy1999@hotmail.com) |
| 英文摘要 | Hiv-1 co-receptor tropism is central for understanding the transmission and pathogenesis of hiv-1 infection. we performed a genome-wide comparison between the adaptive evolution of r5 and x4 variants from hiv-1 subtypes b and c. the results showed that r5 and x4 variants experienced differential evolutionary patterns and different hiv-1 genes encountered various positive selection pressures, suggesting that complex selection pressures are driving hiv-1 evolution. compared with other hypervariable regions of gp120, significantly more positively selected sites were detected in the v3 region of subtype b x4 variants, v2 region of subtype b r5 variants, and v1 and v4 regions of subtype c x4 variants, indicating an association of positive selection with co-receptor recognition/binding. intriguingly, a significantly higher proportion (33.3% and 55.6%, p < 0.05) of positively selected sites were identified in the c3 region than other conserved regions of gp120 in all the analyzed hiv-1 variants, indicating that the c3 region might be more important to hiv-1 adaptation than previously thought. approximately half of the positively selected sites identified in the env gene were identical between r5 and x4 variants. there were three common positively selected sites (96, 113 and 281) identified in gp41 of all x4 and r5 variants from subtypes b and c. these sites might not only suggest a functional importance in viral survival and adaptation, but also imply a potential cross-immunogenicity between hiv-1 r5 and x4 variants, which has important implications for aids vaccine development. |
| WOS关键词 | AMINO-ACID SITES ; ADAPTIVE MOLECULAR EVOLUTION ; VIRUS TYPE-1 INFECTION ; DISEASE PROGRESSION ; ENV GENE ; V3 LOOP ; NEUTRALIZING ANTIBODY ; MAXIMUM-LIKELIHOOD ; HUMORAL IMMUNITY ; ENVELOPE |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| 出版者 | SCIENCE CHINA PRESS |
| WOS记录号 | WOS:000283120000007 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375811 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhang ChiYu |
| 作者单位 | 1.Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, HIV Mol Epidemiol & Virol Res Grp, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang ChiYu,Ding Na,Chen KePing,et al. Complex positive selection pressures drive the evolution of hiv-1 with different co-receptor tropisms[J]. Science china-life sciences,2010,53(10):1204-1214. |
| APA | Zhang ChiYu,Ding Na,Chen KePing,&Yang RongGe.(2010).Complex positive selection pressures drive the evolution of hiv-1 with different co-receptor tropisms.Science china-life sciences,53(10),1204-1214. |
| MLA | Zhang ChiYu,et al."Complex positive selection pressures drive the evolution of hiv-1 with different co-receptor tropisms".Science china-life sciences 53.10(2010):1204-1214. |
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