| Prevalence and genetic diversity of adeno-associated viruses in bats from china | |
| Li, Yan1; Ge, Xingyi1; Hon, Chung-Chau2; Zhang, Huajun1; Zhou, Peng1; Zhang, Yunzhi1,3; Wu, Yi4; Wang, Lin-Fa4; Shi, Zhengli1 | |
| 刊名 | Journal of general virology
 |
| 2010-10-01 | |
| 卷号 | 91页码:2601-2609 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/vir.0.020032-0 |
| 通讯作者 | Shi, zhengli() |
| 英文摘要 | Bats are increasingly being recognized as important natural reservoirs of different viruses adeno-associated viruses (aavs) are widely distributed in primates and their distribution in bats is unknown. in this study, a total of 370 faecal swab samples from 19 bat species were collected from various provinces of china and examined for the presence of aavs the mean prevalence rate was 22.4 % (83 positives out of 370 samples), ranging from 10 to 38 9% among different bat species the genome sequence spanning the entire rep-cap orfs was determined from one chosen aav-positive sample (designated btaav-ynm). phylogenetic analysis of the entire rep-cap orf coding sequences suggested that btaav-ynm is relatively distant to known primate aavs, but phylogenetically closer to porcine aav strain po3 further analysis of the partial cap orf sequences of bat aav samples (n=49) revealed a remarkably large genetic diversity, with an average pairwise nucleotide identity of only 84 3% co-presence of multiple distinctive genotypes of bat aav within an individual sample was also observed. these results demonstrated that diverse aavs might be widely distributed in bat populations |
| WOS关键词 | DNA AMPLIFICATION ; HUMAN TISSUES ; PARVOVIRUS ; CLONING ; PARTICLES ; ADENOVIRUS ; SEQUENCES ; THERAPY ; CELLS ; RECOMBINATION |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| 出版者 | SOC GENERAL MICROBIOLOGY |
| WOS记录号 | WOS:000283004800022 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375803 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shi, Zhengli |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 2.INSERM, U389, Unite Biol Cellulaire Parasitisme, F-75654 Paris 13, France 3.Yunnan Inst Endem Dis Control & Prevent, Dali, Peoples R China 4.Australian Anim Hlth Lab, CSIRO Livestock Ind, Geelong, Vic, Australia |
| 推荐引用方式 GB/T 7714 | Li, Yan,Ge, Xingyi,Hon, Chung-Chau,et al. Prevalence and genetic diversity of adeno-associated viruses in bats from china[J]. Journal of general virology,2010,91:2601-2609. |
| APA | Li, Yan.,Ge, Xingyi.,Hon, Chung-Chau.,Zhang, Huajun.,Zhou, Peng.,...&Shi, Zhengli.(2010).Prevalence and genetic diversity of adeno-associated viruses in bats from china.Journal of general virology,91,2601-2609. |
| MLA | Li, Yan,et al."Prevalence and genetic diversity of adeno-associated viruses in bats from china".Journal of general virology 91(2010):2601-2609. |
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