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	Molecular characterization of avian influenza virus (h7n8) isolated from poultry in central china in the mid-1980s
	Yang JiaLin; Xia Han; Zhao JiuRu; He XiaoBin; Pan LiMin; Tang Shuang; Zhang Zhong; Kou Zheng; Li TianXian
刊名	Chinese science bulletin
	2010-06-01
卷号	55期号:16页码:1625-1630
关键词	Avian influenza virus Low pathogenicity H7n8 H5n1
ISSN号	1001-6538
DOI	10.1007/s11434-010-3148-x
通讯作者	Kou zheng(kouzheng@wh.iov.cn)
英文摘要	The molecular and pathogenic properties of avian influenza virus (a/duck/hubei/216/1985/h7n8) isolated from hubei province of china in 1985 were characterized. the hemagglutinin gene (ha) of dk/hb/216/85/h7n8 had the multiple amino acid sequences (-peipkgrg-) at the connecting peptide between ha1 and ha2, which is considered to be a distinguishing molecular characteristic of low pathogenicity. the key sites of host markers among the genes (m, np, ns, pa and pb2) of dk/hb/216/85/h7n8 were similar to those of h5n1 viruses. phylogenetic analysis showed that the genes (m, ns and pb2) of dk/hb/216/85/h7n8 clustered closely with those of gs/guangdong/1996/h5n1 (gs/gd/96), implying that three ancient genes of gs/gd/96-like viruses had been circulating in central china during the 1980s. in experimental infection, dk/hb/216/85/h7n8 was lowly pathogenic to chickens and mice, consistent with the molecular feature of ha gene.
WOS关键词	A VIRUSES ; H5N1 VIRUSES ; HONG-KONG ; HEMAGGLUTININ ; TRANSMISSION ; ORIGIN
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000278704200009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375757
专题	武汉病毒研究所
通讯作者	Kou Zheng
作者单位	Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Yang JiaLin,Xia Han,Zhao JiuRu,et al. Molecular characterization of avian influenza virus (h7n8) isolated from poultry in central china in the mid-1980s[J]. Chinese science bulletin,2010,55(16):1625-1630.
APA	Yang JiaLin.,Xia Han.,Zhao JiuRu.,He XiaoBin.,Pan LiMin.,...&Li TianXian.(2010).Molecular characterization of avian influenza virus (h7n8) isolated from poultry in central china in the mid-1980s.Chinese science bulletin,55(16),1625-1630.
MLA	Yang JiaLin,et al."Molecular characterization of avian influenza virus (h7n8) isolated from poultry in central china in the mid-1980s".Chinese science bulletin 55.16(2010):1625-1630.

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