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	Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation
	Li, Feng1,2; Li, Ke1,2; Cui, Zong-Qiang1; Zhang, Zhi-Ping1; Wei, Hong-Ping1; Gao, Ding1,2; Deng, Jiao-Yu1; Zhang, Xian-En1
刊名	Small
	2010-10-18
卷号	6期号:20页码:2301-2308
ISSN号	1613-6810
DOI	10.1002/smll.201001078
通讯作者	Zhang, xian-en(x.zhang@wh.iov.cn)
英文摘要	Viral capsid-nanoparticle hybrid structures offer new opportunities for nanobiotechnology. we previously generated virus-based nanoparticles (vnps) of simian virus 40 (sv40) containing quantum dots (qds) for cellular imaging. however, as an interesting issue of nano-bio interfaces, the mechanism of nanoparticle (np) encapsulation by viral coat proteins remains unclear. here, four kinds of qds with the same core/shell but different surface coatings are tested for encapsulation. all the qds can be encapsulated efficiently and there is no correlation between the encapsulation efficiency and the surface charge of the qds. all the sv40 vnps encapsulating differently modified qds show similar structures, fluorescence properties, and activity in entering living cells. these results demonstrate the flexibility of sv40 major capsid protein vp1 in np encapsulation and provide new clues to the mechanism of np packaging by viral shells.
WOS关键词	MINOR CAPSID PROTEINS ; VIRUS-LIKE PARTICLES ; GOLD NANOPARTICLES ; IN-VITRO ; SIMIAN-VIRUS-40 ; VP1 ; ENCAPSIDATION ; POLYOMAVIRUS ; RESOLUTION ; GENOME
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000283890500015
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375720
专题	武汉病毒研究所
通讯作者	Zhang, Xian-En
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Feng,Li, Ke,Cui, Zong-Qiang,et al. Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation[J]. Small,2010,6(20):2301-2308.
APA	Li, Feng.,Li, Ke.,Cui, Zong-Qiang.,Zhang, Zhi-Ping.,Wei, Hong-Ping.,...&Zhang, Xian-En.(2010).Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation.Small,6(20),2301-2308.
MLA	Li, Feng,et al."Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation".Small 6.20(2010):2301-2308.

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