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	The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation
	Li, Hongxia1,2; Zheng, Zhenhua1,2; Zhou, Peng1,2; Zhang, Bing1,2; Shi, Zhengli1; Hu, Qinxue1; Wang, Hanzhong1
刊名	Journal of general virology
	2010-12-01
卷号	91页码:2947-2958
ISSN号	0022-1317
DOI	10.1099/vir.0.025205-0
通讯作者	Wang, hanzhong()
英文摘要	There is growing evidence that porcine reproductive and respiratory syndrome virus (prrsv) has developed mechanisms to subvert the host innate immune response prrsv non-structural protein 2 (nsp2) was suggested previously as a potential interferon (ifn) antagonist this study focused on nsp2 to investigate its inhibitory mechanism of ifn induction it was demonstrated that nsp2 strongly inhibited ifn-beta production by antagonizing activation of the ifn regulatory factor 3 (irf-3) pathway induced by the sendai virus (sev) further studies revealed that the cysteine protease domain (pl2) of nsp2 was necessary for ifn antagonism additionally, both full-length nsp2 and the pl2 protease domain of nsp2 were found to inhibit sev-induced phosphorylation and nuclear translocation of irf-3 these findings suggest that nsp2 is likely to play an important role in subversion of irf-3-dependent innate antiviral defences, providing a basis for elucidating the mechanisms underlying prrsv pathogenesis
WOS关键词	PAPAIN-LIKE PROTEASE ; DOUBLE-STRANDED-RNA ; SYNDROME CORONAVIRUS ; I INTERFERON ; RIG-I ; ANTIVIRAL RESPONSES ; SIGNALING PATHWAY ; GENE-EXPRESSION ; IMMUNE-RESPONSES ; MARC-145 CELLS
WOS研究方向	Biotechnology & Applied Microbiology ; Virology
WOS类目	Biotechnology & Applied Microbiology ; Virology
语种	英语
出版者	SOC GENERAL MICROBIOLOGY
WOS记录号	WOS:000285221000007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375704
专题	武汉病毒研究所
通讯作者	Wang, Hanzhong
作者单位	1.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongxia,Zheng, Zhenhua,Zhou, Peng,et al. The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation[J]. Journal of general virology,2010,91:2947-2958.
APA	Li, Hongxia.,Zheng, Zhenhua.,Zhou, Peng.,Zhang, Bing.,Shi, Zhengli.,...&Wang, Hanzhong.(2010).The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation.Journal of general virology,91,2947-2958.
MLA	Li, Hongxia,et al."The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation".Journal of general virology 91(2010):2947-2958.

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