QQ客服 官方微博 反馈留言

	Anti-mrsa and anti-tb metabolites from marine-derived verrucosispora sp ms100047
	Huang, Pei1,2; Xie, Feng1,3; Ren, Biao1,4; Wang, Qian1,2; Wang, Jian1; Wang, Qi1,2; Abdel-Mageed, Wael M.1,5; Liu, Miaomiao1,2,6; Han, Jianying1,2; Oyeleye, Ayokunmi7
刊名	Applied microbiology and biotechnology
	2016-09-01
卷号	100期号:17页码:7437-7447
关键词	Salicylic derivative Anti-mrsa Anti-bcg Marine-derived verrucosispora
ISSN号	0175-7598
DOI	10.1007/s00253-016-7406-y
通讯作者	Liu, xueting(liuxueting_cn@hotmail.com) ; Zhang, lixin(zhanglixin@im.ac.cn)
英文摘要	Microbes belonging to the genus verrucosispora possess significant chemical diversity and biological properties. they have attracted the interests of many researchers and are becoming promising resources in the marine natural product research field. a bioassay-guided isolation from the crude extract of verrucosispora sp. strain ms100047, isolated from sediments collected from the south china sea, has led to the identification of a new salicylic derivative, glycerol 1-hydroxy-2,5-dimethyl benzoate (1), along with three known compounds, brevianamide f (2), abyssomicin b (3), and proximicin b (4). compound 1 showed selective activity against methicillin-resistant staphylococcus aureus (mrsa) with a minimum inhibitory concentration (mic) value of 12.5 mu g/ml. brevianamide f (2), which was isolated from actinomycete for the first time, showed a good anti-bcg activity with a mic value of 12.5 mu g/ml that has not been reported previously in literatures. proximicin b (4) showed significant anti-mrsa (mic = 3.125 mu g/ml), anti-bcg (mic = 6.25 mu g/ml), and anti-tuberculosis (tb) (mic = 25 mu g/ml) activities. this is the first report on the anti-tubercular activities of proximicins. in addition, verrucosispora sp. strain ms100047 was found to harbor 18 putative secondary metabolite gene clusters based on genomic sequence analysis. these include the biosynthetic loci encoding polyketide synthase (pks) and non-ribosomal peptide synthetase (nrps) consistent with abyssomicins and proximicins, respectively. the biosynthetic pathways of these isolated compounds have been proposed. these results indicate that ms100047 possesses a great potential as a source of active secondary metabolites.
WOS关键词	NATURAL-PRODUCTS ; ASPERGILLUS-FUMIGATUS ; STRAIN AB-18-032 ; ABYSSOMICIN-C ; BIOSYNTHESIS ; PATHWAY ; IDENTIFICATION ; POLYKETIDE ; BACTERIAL ; DISCOVERY
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000381583400007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375449
专题	中国科学院大学
通讯作者	Liu, Xueting; Zhang, Lixin
作者单位	1.Chinese Acad Sci, Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China 4.Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China 5.Assiut Univ, Dept Pharmacognosy, Fac Pharm, Assiut 71526, Egypt 6.Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia 7.Forestry Res Inst Nigeria, Ibadan, Nigeria
推荐引用方式 GB/T 7714	Huang, Pei,Xie, Feng,Ren, Biao,et al. Anti-mrsa and anti-tb metabolites from marine-derived verrucosispora sp ms100047[J]. Applied microbiology and biotechnology,2016,100(17):7437-7447.
APA	Huang, Pei.,Xie, Feng.,Ren, Biao.,Wang, Qian.,Wang, Jian.,...&Zhang, Lixin.(2016).Anti-mrsa and anti-tb metabolites from marine-derived verrucosispora sp ms100047.Applied microbiology and biotechnology,100(17),7437-7447.
MLA	Huang, Pei,et al."Anti-mrsa and anti-tb metabolites from marine-derived verrucosispora sp ms100047".Applied microbiology and biotechnology 100.17(2016):7437-7447.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。