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	Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1
	Ye, Feng-Chun; Blackbourn, David J.; Mengel, Michael; Xie, Jian-Ping; Qian, Li-Wu; Greene, Whitney; Yeh, I-Tien; Graham, David; Gao, Shou-Jiang
刊名	Journal of virology
	2007-04-01
卷号	81期号:8页码:3980-3991
ISSN号	0022-538X
DOI	10.1128/jvi.02089-06
通讯作者	Gao, shou-jiang(gaos@uthscsa.edu)
英文摘要	Infection by kaposi's sarcoma-associated herpesvirus (kshv) is required for the development of kaposi's sarcoma (ks), a highly inflammatory angiogenic tumor of endothelial cells commonly found in untreated aids patients. angiopoietin 2 (ang-2) modulates the vasculature during inflammation and angiogenesis, but the mechanism by which kshv regulates ang-2 expression has not been investigated. here, we show that kshv infection of primary human umbilical vein endothelial cells induced the expression and release of ang-2, which in turn was required for kshv-induced paracrine-dependent angiogenesis in vivo. ang-2 was strongly expressed in small vessels and spindle tumor cells in ks tumors. mechanistically, kshv activated the ang-2 promoter via ap-1 and ets1 transcriptional factors, which were mediated by erk, jnk, and p38 mitogen-activated protein kinase (mapk) pathways. our findings demonstrate the importance of ang-2 in ks angiogenesis and define a novel role for ap-1 and mapk pathways in regulating angiogenesis. this study also illustrates a distinct mechanism by which a tumor virus modulates vasculature to promote tumorigenesis and exemplifies the convergence of oncogenesis and angiogenesis pathways in tumor development.
WOS关键词	MICROVASCULAR ENDOTHELIAL-CELLS ; ACTIVATED PROTEIN-KINASE ; NF-KAPPA-B ; TYRAMINE AMPLIFICATION TECHNIQUE ; PRIMARY-EFFUSION LYMPHOMA ; GROWTH-FACTOR EXPRESSION ; TUMOR ANGIOGENESIS ; PRIMARY INFECTION ; GENE-EXPRESSION ; IN-VIVO
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000245692900030
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375404
专题	武汉病毒研究所
通讯作者	Gao, Shou-Jiang
作者单位	1.Univ Texas, Hlth Sci Ctr, Tumor Virol Program, Childrens Canc Res Inst, San Antonio, TX 78229 USA 2.Univ Texas, Hlth Sci Ctr, Dept Pediat, San Antonio, TX 78229 USA 3.Univ Texas, Hlth Sci Ctr, Dept Microbiol & Immunol, San Antonio, TX 78229 USA 4.Univ Texas, Hlth Sci Ctr, Dept Mol Med, San Antonio, TX 78229 USA 5.Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA 6.Univ Texas, Hlth Sci Ctr, San Antonio Canc Inst, San Antonio, TX 78229 USA 7.Chinese Acad Sci, Wuhan Inst Virol, Tumor Virol Grp, Wuhan, Peoples R China 8.Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham, W Midlands, England 9.Med Hochsch Hannover, Inst Pathol, Hannover, Germany
推荐引用方式 GB/T 7714	Ye, Feng-Chun,Blackbourn, David J.,Mengel, Michael,et al. Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1[J]. Journal of virology,2007,81(8):3980-3991.
APA	Ye, Feng-Chun.,Blackbourn, David J..,Mengel, Michael.,Xie, Jian-Ping.,Qian, Li-Wu.,...&Gao, Shou-Jiang.(2007).Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1.Journal of virology,81(8),3980-3991.
MLA	Ye, Feng-Chun,et al."Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1".Journal of virology 81.8(2007):3980-3991.

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