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	Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection
	Wu, Fengchi1,2,3; Wu, Yuqiang3; Niu, Zhongwei1; Vollmer, Frank3,4
刊名	Sensors
	2016-08-01
卷号	16期号:8页码:10
关键词	Whispering gallery mode Dna strand displacement Mercury (ii) ions detection Biosensing Label-free detection Optical microcavity Dna nanotechnology
ISSN号	1424-8220
DOI	10.3390/s16081197
通讯作者	Vollmer, frank(frank.vollmer@mpl.mpg.de)
英文摘要	Mercury is an extremely toxic chemical pollutant of our environment. it has attracted the world's attention due to its high mobility and the ease with which it accumulates in organisms. sensitive devices and methods specific for detecting mercury ions are, hence, in great need. here, we have integrated a dna strand displacement reaction with a whispering gallery mode (wgm) sensor for demonstrating the detection of hg2+ ions. our approach relies on the displacement of a dna hairpin structure, which forms after the binding of mercury ions to an aptamer dna sequence. the strand displacement reaction of the dna aptamer provides highly specific and quantitative means for determining the mercury ion concentration on a label-free wgm sensor platform. our approach also shows the possibility for manipulating the kinetics of a strand displacement reaction with specific ionic species.
WOS关键词	GOLD NANOPARTICLES ; FREE MICROCAVITY ; HG2+ ; PROTEIN ; FLUORESCENT ; RESONATORS ; BIOSENSOR ; APTAMER ; CATION ; SHIFT
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS类目	Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000382323200185
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375353
专题	中国科学院大学
通讯作者	Vollmer, Frank
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 3.Max Planck Inst Sci Light, Lab Nanophoton & Biosensing, D-91058 Erlangen, Germany 4.Harvard Med Sch, Brigham & Womens Hosp, Div Biomed Engn, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Wu, Fengchi,Wu, Yuqiang,Niu, Zhongwei,et al. Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection[J]. Sensors,2016,16(8):10.
APA	Wu, Fengchi,Wu, Yuqiang,Niu, Zhongwei,&Vollmer, Frank.(2016).Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection.Sensors,16(8),10.
MLA	Wu, Fengchi,et al."Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection".Sensors 16.8(2016):10.

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