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	Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres
	Zhu, Xinyun; Wang, Cai-Qi
刊名	Journal of colloid and interface science
	2016-10-15
卷号	480页码:39-48
关键词	Hollow mesoporous silica spheres Dual-responsive Supramolecular nanovalve Cargo size-selective Drug delivery system
ISSN号	0021-9797
DOI	10.1016/j.jcis.2016.06.043
通讯作者	Wang, cai-qi(wang-caiqi@ucas.ac.cn)
英文摘要	A ph and redox dual-responsive nanovalve with a long stalk was introduced on the surface of hollow mesoporous silica nanoparticles (hmss-s1) to achieve cargo size selectivity delivery. the responsive nanovalve was designed by constructing of a stalk/beta-cyclodextrins (cds) supramolecular complex, which is based on an acid-labile acetal group and the host-guest interactions between beta-cyclodextrins and ferrocenyl moiety (fc). with stimulation by different ph and h2o2, rhodamine 6g showed well-responsive behavior. on account of the long stalks of nanovalve, doxorubicin hydrochloride and 5-fluorouracil with different sized cargos are encapsulated in hmss-s1 to test its behavior of cargo size-selective delivery. moreover the hmss-s2 with a short stalk based on beta-cds/fc inclusion complex is synthesized to load small sized 5-fu drug as contrast experiment. compared with hmss-s2, hmss-s1 is compatible with larger drug molecules such as rhodamine 6g (r6g) and doxorubicin hydrochloride (dox), while small sized 5-fluorouracil (5-fu) is unable to be sealed by the nanovalve. dual responsiveness and drug size selectivity make mechanized hmss possess potential applications in drug delivery system. (c) 2016 elsevier inc. all rights reserved.
WOS关键词	RESPONSIVE DRUG-DELIVERY ; CONTROLLED-RELEASE ; IN-VITRO ; INTRACELLULAR DELIVERY ; NANOPARTICLES ; ACID ; CYCLODEXTRIN ; MOLECULES ; CANCER ; PSEUDOROTAXANES
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000381244900005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375336
专题	中国科学院大学
通讯作者	Wang, Cai-Qi
作者单位	Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Xinyun,Wang, Cai-Qi. Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres[J]. Journal of colloid and interface science,2016,480:39-48.
APA	Zhu, Xinyun,&Wang, Cai-Qi.(2016).Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres.Journal of colloid and interface science,480,39-48.
MLA	Zhu, Xinyun,et al."Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres".Journal of colloid and interface science 480(2016):39-48.

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