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	Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma
	Zhang, Bao1,2,3; Wang, Dongpeng1,2,3; Wu, Jing4; Tang, Jun5; Chen, Weixiong5; Chen, Xiaomin1,2; Zhang, Dongdong1,2; Deng, Yanming4; Guo, Mingzhou6; Wang, Yuejian5
刊名	Discovery medicine
	2016-04-01
卷号	21期号:116页码:239-250
ISSN号	1539-6509
通讯作者	Wang, yuejian(wyjian@fsyyy.com) ; Luo, jianjun(luojianj@moon.ibp.ac.cn) ; Chen, runsheng(rschen@ibp.ac.cn)
英文摘要	Rapidly growing evidence has shown that long noncoding rnas (lncrnas) are playing more and more important roles in a variety of biological processes and have been involved in various types of cancer. how to better decode these noncoding transcripts and how to predict their potential roles in tumorigenesis particularly in nasopharyngeal carcinoma (npc) are still open questions. in this study, we applied our custom-designed lncrna+mrna gene expression microarray, which contains probes against 38,141 lncrna transcripts, to assaying the expression profiling of flash-frozen tumorous and non-tumorous tissue samples from nonkeratinizing carcinoma (nkc), which is the major histologic type of npc. as a result, 481 differentially expressed (de) lncrnas (231 up-regulated and 250 down-regulated) were identified. moreover, integrated bioinformatics analyses including gene ontology, lncrna functional prediction based on coding-noncoding gene co-expression network, interactive mirnas, and transcription factor binding motifs were all carried out to decode the potential functional roles of these newly identified de-lncrnas. this work hence offers new resource and insight into lncrnas for further understanding the molecular mechanisms of tumorigenesis of nkc, and may also define new biomarkers or therapy targets for the translational studies of nkc.
WOS关键词	GENE COEXPRESSION NETWORK ; TRANSCRIPTION ; CANCER ; PROGRESSION ; ACTIVATION ; CHROMATIN ; MARKER ; LNCRNA ; CELLS
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
语种	英语
出版者	DISCOVERY MEDICINE
WOS记录号	WOS:000376677700002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375075
专题	中国科学院大学
通讯作者	Wang, Yuejian; Luo, Jianjun; Chen, Runsheng
作者单位	1.Chinese Acad Sci, Key Lab RNA Biol, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Noncoding RNA, Inst Biophys, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.First Peoples Hosp Foshan, Canc Ctr, Foshan 528000, Guangdong, Peoples R China 5.First Peoples Hosp Foshan, Dept Otolaryngol, Foshan 528000, Guangdong, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Bao,Wang, Dongpeng,Wu, Jing,et al. Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma[J]. Discovery medicine,2016,21(116):239-250.
APA	Zhang, Bao.,Wang, Dongpeng.,Wu, Jing.,Tang, Jun.,Chen, Weixiong.,...&Chen, Runsheng.(2016).Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma.Discovery medicine,21(116),239-250.
MLA	Zhang, Bao,et al."Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma".Discovery medicine 21.116(2016):239-250.

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