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	Immunomodulation of artemisinin and its derivatives
	Yao, Wenbo1,2; Wang, Feng3; Wang, Hui1,2,3,4
刊名	Science bulletin
	2016-09-01
卷号	61期号:18页码:1399-1406
关键词	Artemisinin Immune system Immune-related diseases Macrophage T-cell B-cell
ISSN号	2095-9273
DOI	10.1007/s11434-016-1105-z
通讯作者	Wang, hui(huiwang@sibs.ac.cn)
英文摘要	In the 1970s, artemisinin ("qinghaosu" in chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from artemisia annua l. it showed promising antimalarial activity, particularly by eliminating parasites resistant to chloroquine. for more than 30 years, artemisinin has contributed to worldwide health as a new type of antimalarial drug. artemisinin and its analogs, such as dihydroartemisinin, artemether, artesunate, artemiside, artemisone, and arteether, possess not only potent antimalarial activity but also anti-viral, antifungal, anticancer, and anti-inflammatory properties. in this review, we discuss the current understanding of how artemisinin and its analogs affect the immune system and immune-related diseases.
WOS关键词	NF-KAPPA-B ; EXPERIMENTAL RHEUMATOID-ARTHRITIS ; PLASMODIUM-FALCIPARUM MALARIA ; ANTIMALARIAL AGENT ARTESUNATE ; ESCHERICHIA-COLI CHALLENGE ; COLLAGEN-INDUCED ARTHRITIS ; MESSENGER-RNA EXPRESSIONS ; SUB-SAHARAN AFRICA ; T-CELL-ACTIVATION ; SEPSIS MODEL MICE
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000384566600002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375042
专题	中国科学院大学
通讯作者	Wang, Hui
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China
推荐引用方式 GB/T 7714	Yao, Wenbo,Wang, Feng,Wang, Hui. Immunomodulation of artemisinin and its derivatives[J]. Science bulletin,2016,61(18):1399-1406.
APA	Yao, Wenbo,Wang, Feng,&Wang, Hui.(2016).Immunomodulation of artemisinin and its derivatives.Science bulletin,61(18),1399-1406.
MLA	Yao, Wenbo,et al."Immunomodulation of artemisinin and its derivatives".Science bulletin 61.18(2016):1399-1406.

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