| Beta-arrestin-1 contributes to brown fat function and directly interacts with ppar alpha and ppar gamma | |
| Wang, Congcong1,2; Zeng, Xianglu1,3,4; Zhou, Zhaocai1; Zhao, Jian1,4; Pei, Gang1,5,6 | |
| 刊名 | Scientific reports
 |
| 2016-06-15 | |
| 卷号 | 6页码:11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep26999 |
| 通讯作者 | Zhao, jian(jzhao@sibcb.ac.cn) ; Pei, gang(gpei@sibs.ac.cn) |
| 英文摘要 | The peroxisome proliferator-activated receptor (ppar) family plays central roles in brown adipose tissue (bat) adipogenesis and contributes to body temperature maintenance. the transcriptional activity of ppar family has been shown to be tightly controlled by cellular signal networks. beta-arrestins function as major secondary messengers of g protein-coupled receptors (gpcr) signaling by functional interactions with diverse proteins. here, we report that beta-arrestin-1 knock-out mice show enhanced cold tolerance. we found that beta-arrestin-1 directly interacts with ppar alpha and ppar gamma through a lxxxlxxxl motif, while d371 in ppar alpha and l311/n312/d380 in ppar gamma are required for their interactions with beta-arrestin-1. further mechanistic studies showed that beta-arrestin-1 promotes ppar alpha- but represses ppar gamma-mediated transcriptional activities, providing potential regulatory pathway for bat function. |
| WOS关键词 | ACTIVATED RECEPTOR-GAMMA ; GENE-EXPRESSION ; WHITE FAT ; ADIPOCYTE DIFFERENTIATION ; HORMONE-RECEPTORS ; CRYSTAL-STRUCTURE ; ADIPOSE-TISSUE ; BETA-ARRESTIN ; PROTEIN ; BINDING |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000384616200001 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375038 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, Jian; Pei, Gang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China 3.Tongji Univ, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China 4.Tongji Univ, Sch Med, Shanghai East Hosp, Translat Med Ctr Stem Cell Therapy, Shanghai 200120, Peoples R China 5.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China 6.Tongji Univ, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Congcong,Zeng, Xianglu,Zhou, Zhaocai,et al. Beta-arrestin-1 contributes to brown fat function and directly interacts with ppar alpha and ppar gamma[J]. Scientific reports,2016,6:11. |
| APA | Wang, Congcong,Zeng, Xianglu,Zhou, Zhaocai,Zhao, Jian,&Pei, Gang.(2016).Beta-arrestin-1 contributes to brown fat function and directly interacts with ppar alpha and ppar gamma.Scientific reports,6,11. |
| MLA | Wang, Congcong,et al."Beta-arrestin-1 contributes to brown fat function and directly interacts with ppar alpha and ppar gamma".Scientific reports 6(2016):11. |
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