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	Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice
	Li, Hongyan1,2,3; He, Yuxuan4; Yan, Jiawei1,2,3,5; Zhao, Qiuyue1,2,3; Di, Cuixia1,2,3; Zhang, Hong1,2,3
刊名	Reproductive toxicology
	2016-10-01
卷号	65页码:148-158
关键词	Proteomics Sperm Motility Space radiation
ISSN号	0890-6238
DOI	10.1016/j.reprotox.2016.07.014
通讯作者	Zhang, hong(zhangh@impcas.ac.cn)
英文摘要	The toxicological mechanism of low sperm motility induced by iron ion radiation (iir) was investigated in mice. reproductive organ indices were measured following whole-body irradiation with a 2 gy iron ion beam. two-dimensional gel electrophoresis, immunoblotting and immunofluorescence were used to analyze protein expression, and real-time polymerase chain reaction was performed to confirm altered gene expression. reproductive organ indices and sperm motility were lowest 2 weeks after iir. sperm function changes via testis and cauda epididymis function were also determined at this time point. sixteen differentially expressed proteins were identified in sperm 2 weeks after iir. bioinformatics analysis indicated that alpha-enolase (enol) may be important in the regulation of glycolysis in sperm, and enol expression was correlated with sperm motility. enol may be a potential marker for low sperm motility induced by iir, and these results may provide a useful reference for changes in astronaut fertility during long space missions. (c) 2016 elsevier inc. all rights reserved.
WOS关键词	CREATINE-KINASE ; GFAP EXPRESSION ; SPACE RADIATION ; MOUSE TESTIS ; CELL-LINE ; IN-VITRO ; SPERMATOZOA ; MEN ; INFERTILITY ; IRRADIATION
WOS研究方向	Reproductive Biology ; Toxicology
WOS类目	Reproductive Biology ; Toxicology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000385990900018
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374999
专题	中国科学院大学
通讯作者	Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Peoples R China 4.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongyan,He, Yuxuan,Yan, Jiawei,et al. Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice[J]. Reproductive toxicology,2016,65:148-158.
APA	Li, Hongyan,He, Yuxuan,Yan, Jiawei,Zhao, Qiuyue,Di, Cuixia,&Zhang, Hong.(2016).Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice.Reproductive toxicology,65,148-158.
MLA	Li, Hongyan,et al."Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice".Reproductive toxicology 65(2016):148-158.

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