An improved ph-responsive carrier based on edta-ca-alginate for oral delivery of lactobacillus rhamnosus atcc 53103 | |
Zheng, Huizhen1,3; Gao, Meng1,3; Ren, Ying1,3; Lou, Ruyun1,3; Xie, Hongguo1; Yu, Weiting1; Liu, Xiudong2; Ma, Xiaojun1 | |
刊名 | Carbohydrate polymers |
2017-01-02 | |
卷号 | 155页码:329-335 |
关键词 | Hydrogel Edta-ca-alg Ph-responsive carrier Lactobacillus rhamnosus atcc 53103 Controlled release |
ISSN号 | 0144-8617 |
DOI | 10.1016/j.carbpol.2016.08.096 |
通讯作者 | Yu, weiting(yuwt@dicp.ac.cn) ; Liu, xiudong(liuxd@dicp.ac.cn) |
英文摘要 | A ph-responsive carrier based on an ethylenediaminetetraacetic-calcium-alginate (edta-ca-alg) system was developed by controlling the release of ca2+. the system remained in the solution state at neutral ph since edta completely chelated the ca2+. in contrast, a hydrogel immediately formed when the ph was below 4.0, which triggered the in situ release of ca2+ from the edta-ca compound and led to alginate-ca binding. taking advantage of the ph sensitivity, we prepared hydrogel microspheres with uniform size to entrap lactobacillus rhamnosus atcc 53103 through emulsification. in an acidic environment, the hydrogel structure remained compact with, negligible pores to protect l. rhamnosus atcc 53103. however, in a neutral intestinal environment, the hydrogel structure gradually disassembled because of the ca2+ release from the hydrogel, which caused cell release. therefore, a ph-responsive carrier was developed for the protection and the controlled release of cells in gastrointestinal tract, thus providing potential for oral delivery of probiotics. (c) 2016 elsevier ltd. all rights reserved. |
WOS关键词 | MICROENCAPSULATION ; PROBIOTICS ; ENCAPSULATION ; BACTERIA ; CHITOSAN ; GELATION |
WOS研究方向 | Chemistry ; Polymer Science |
WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000386402600035 |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/2374952 |
专题 | 中国科学院大学 |
通讯作者 | Yu, Weiting; Liu, Xiudong |
作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Zheng, Huizhen,Gao, Meng,Ren, Ying,et al. An improved ph-responsive carrier based on edta-ca-alginate for oral delivery of lactobacillus rhamnosus atcc 53103[J]. Carbohydrate polymers,2017,155:329-335. |
APA | Zheng, Huizhen.,Gao, Meng.,Ren, Ying.,Lou, Ruyun.,Xie, Hongguo.,...&Ma, Xiaojun.(2017).An improved ph-responsive carrier based on edta-ca-alginate for oral delivery of lactobacillus rhamnosus atcc 53103.Carbohydrate polymers,155,329-335. |
MLA | Zheng, Huizhen,et al."An improved ph-responsive carrier based on edta-ca-alginate for oral delivery of lactobacillus rhamnosus atcc 53103".Carbohydrate polymers 155(2017):329-335. |
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