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	Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis
	Li, Lu1,2; Li, Dan1; Tian, Feng3; Cen, Jin1; Chen, Xiaotao1; Ji, Yuan3; Hui, Lijian1
刊名	Journal of biological chemistry
	2016-09-30
卷号	291期号:40页码:21137-+
ISSN号	0021-9258
DOI	10.1074/jbc.m116.736173
通讯作者	Li, dan(lidan@sibcb.ac.cn) ; Hui, lijian(ljhui@sibcb.ac.cn)
英文摘要	Borealin, a member of the chromosomal passenger complex, plays a key regulatory role at centromeres and the central spindle during mitosis. loss of borealin leads to defective cell proliferation and early embryonic lethality. the in vivo functions of borealin in mammalian postnatal development, tissue homeostasis, and tumorigenesis remain elusive. we specifically analyzed the role of borealin in regulating postnatal liver development, damage-induced liver regeneration, and liver carcinogenesis using mice carrying conditional borealin alleles. perinatal loss of borealin caused increased genome ploidy and enlarged cell size in hepatocytes, likely due to the impaired function of the chromosomal passenger complex in mitosis. borealin deletion also showed attenuated expansion of sox9(+)hnf4 alpha(+) progenitor-like cells in liver regeneration during 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-inducedliverinjury. moreover, delta n90-beta-catenin and c-met-induced hepatocarcinogenesis development was largely impeded by borealin deletion. these findings indicate that borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that borealin could be a potential target for related liver diseases.
WOS关键词	PROGENITOR CELLS ; MATURE HEPATOCYTES ; PROMOTES EXPANSION ; CANCER-CELLS ; STEM-CELLS ; SURVIVIN ; PROTEIN ; AURORA ; PROLIFERATION ; TUMORIGENESIS
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
语种	英语
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
WOS记录号	WOS:000385406200028
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374911
专题	中国科学院大学
通讯作者	Li, Dan; Hui, Lijian
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Shanghai, Peoples R China 3.Fudan Univ, Zhongshan Hosp, Dept Pathol, Fenglin Rd 180, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Lu,Li, Dan,Tian, Feng,et al. Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis[J]. Journal of biological chemistry,2016,291(40):21137-+.
APA	Li, Lu.,Li, Dan.,Tian, Feng.,Cen, Jin.,Chen, Xiaotao.,...&Hui, Lijian.(2016).Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis.Journal of biological chemistry,291(40),21137-+.
MLA	Li, Lu,et al."Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis".Journal of biological chemistry 291.40(2016):21137-+.

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