| Naked-eye visible solid illicit drug detection at picogram level via a multiple-anchored fluorescent probe | |
| Fan, Tianchi1,2; Xu, Wei1,2; Yao, Junjun1,2; Jiao, Zinuo1,2; Fu, Yanyan1,2; Zhu, Defeng1; He, Qingguo1; Cao, Huimin1; Cheng, Jiangong1 | |
| 刊名 | Acs sensors
 |
| 2016-03-01 | |
| 卷号 | 1期号:3页码:312-317 |
| 关键词 | Fluorescence probe Pictogram Ketamines Methylamphetamine Intramolecular dimer |
| ISSN号 | 2379-3694 |
| DOI | 10.1021/acssensors.5b00293 |
| 通讯作者 | He, qingguo(hqg@mail.sim.ac.cn) ; Cheng, jiangong(jgcheng@mail.sim.ac.cn) |
| 英文摘要 | Solid-state fluorescence probes, without the disadvantages of the existing probe in solution or any pretreatment needed for the analytes, are in great need for the detection of abused drugs. the abused drugs exist as salts, which have low reactivity and volatility, so there is a big challenge for the detection using the solid fluorescence sensing method. in this work, for the first time, a simple, rapid, sensitive, and selective solid-state fluorescence probe-an intramolecular dimer of eight benzyl alcohol-substituted fluorenes bridged by a 1,6-hexanyl unit (8ba-2f) has been designed, synthesized, and used in a contact mode for ketamine and methylamphetamine detection without the pretreatment of the drugs. upon contact with the drugs in different concentrations, the emission will show a different emission color, which could be visible with the naked eye. even 50 pg/cm(2) ketamine could be detected by the naked eye. theoretical calculation indicates that there is strong hydrogen bonding interaction between the eight -phch2oh and -nh2+-, which induced a large steric configuration change of 8ba-2f, resulting in significantly enhanced fluorescence at 398 nm, while the emission at 463 nm showed less change. therefore, the ratio change of the emission band peaked at 398 and 463 nm, triggered by a different amount of the drug molecules resulting in a different emission color. together with the characteristics of the dimer such as multiple active sites, moderate interaction force, high steric hindrance related to easy penetration of the drug, the probe showed a sensitive, selective, and rapid sensing performance. |
| WOS关键词 | MASS-SPECTROMETRY ; GAS CHROMATOGRAPHY ; EXPLOSIVE VAPOR ; METHAMPHETAMINE ; AMPHETAMINES ; URINE ; SENSORS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000385464400016 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2374779 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He, Qingguo; Cheng, Jiangong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, State Key Lab Transducer Technol, Changning Rd 865, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Tianchi,Xu, Wei,Yao, Junjun,et al. Naked-eye visible solid illicit drug detection at picogram level via a multiple-anchored fluorescent probe[J]. Acs sensors,2016,1(3):312-317. |
| APA | Fan, Tianchi.,Xu, Wei.,Yao, Junjun.,Jiao, Zinuo.,Fu, Yanyan.,...&Cheng, Jiangong.(2016).Naked-eye visible solid illicit drug detection at picogram level via a multiple-anchored fluorescent probe.Acs sensors,1(3),312-317. |
| MLA | Fan, Tianchi,et al."Naked-eye visible solid illicit drug detection at picogram level via a multiple-anchored fluorescent probe".Acs sensors 1.3(2016):312-317. |
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