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	Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease
	Luo, Hongbo1; Han, Guangchun2; Wang, Jiajia2,3; Zeng, Fan4,5; Li, Yuanming1; Shao, Shaoju1; Song, Fuhai2,3; Bai, Zhouxian2,3; Peng, Xing2,3; Wang, Yan-Jiang4,5
刊名	Molecular neurobiology
	2016-08-01
卷号	53期号:6页码:3596-3605
关键词	Vascular dementia Alzheimer's disease Peripheral blood Gene expression Ribosome
ISSN号	0893-7648
DOI	10.1007/s12035-015-9288-x
通讯作者	Shi, xiangqun(shixq_2003@163.com) ; Lei, hongxing(leihx@big.ac.cn)
英文摘要	Alzheimer's disease (ad) and vascular dementia (vad) are the two most dominant forms of dementia in elderly people. due to the large overlap between ad and vad in clinical observations, great controversies exist regarding the distinction and connection between these two types of senile dementia. here for the first time, we resort to the gene expression pattern of the peripheral blood to compare ad and vad objectively. in our previous work, we have demonstrated that the dysregulation of gene expression in ad is unique among the examined diseases including neurological diseases, cancer, and metabolic diseases. in this study, we found that the dysregulation of gene expression in ad and vad is quite similar to each other at both functional and gene levels. interestingly, the dysregulation started at the early stages of the diseases, namely mild cognitive impairment (mci) and vascular cognitive impairment (vci). we have also shown that this signature is distinctive from that of peripheral vascular diseases. comparison with aging studies revealed that the most profound change in ad and vad, namely ribosome, is consistent with the accelerated aging scenario. this study may have implications to the common mechanism between ad and vad.
WOS关键词	CORONARY-ARTERY-DISEASE ; MILD COGNITIVE IMPAIRMENT ; GENE-EXPRESSION PATTERNS ; WHOLE-BLOOD ; RATING-SCALE ; RISK-FACTORS ; S100A12 ; MARKER ; METAANALYSIS ; METABOLISM
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	HUMANA PRESS INC
WOS记录号	WOS:000379707600008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374510
专题	中国科学院大学
通讯作者	Shi, Xiangqun; Lei, Hongxing
作者单位	1.Lanzhou Mil Area Command, Lanzhou Gen Hosp, Dept Neurol, Lanzhou 730050, Gansu, Peoples R China 2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 100053, Peoples R China 5.Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 100053, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Luo, Hongbo,Han, Guangchun,Wang, Jiajia,et al. Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease[J]. Molecular neurobiology,2016,53(6):3596-3605.
APA	Luo, Hongbo.,Han, Guangchun.,Wang, Jiajia.,Zeng, Fan.,Li, Yuanming.,...&Lei, Hongxing.(2016).Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease.Molecular neurobiology,53(6),3596-3605.
MLA	Luo, Hongbo,et al."Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease".Molecular neurobiology 53.6(2016):3596-3605.

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