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	Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration
	Shi, Yaoyao1,2; Wu, Weiwei1,2; Chai, Qian1; Li, Qingqing3; Hou, Yu3; Xia, Huan1,2; Ren, Boyang1,2; Xu, Hairong1; Guo, Xiaohuan4; Jin, Caiwei1,2
刊名	Nature communications
	2016-08-01
卷号	7页码:12
ISSN号	2041-1723
DOI	10.1038/ncomms12369
通讯作者	Zhu, mingzhao(zhumz@ibp.ac.cn)
英文摘要	Continuous thymic homing of haematopoietic progenitor cells (hpcs) via the blood is critical for normal t-cell development. however, the nature and the differentiation programme of specialized thymic endothelial cells (ecs) controlling this process remain poorly understood. here using conditional gene-deficient mice, we find that lymphotoxin beta receptor (ltbr) directly controls thymic ecs to guide hpc homing. interestingly, t-cell deficiency or conditional ablation of t-cell-engaged ltbr signalling results in a defect in thymic hpc homing, suggesting the feedback regulation of thymic progenitor homing by thymic products. furthermore, we identify and characterize a special thymic portal ec population with features that guide hpc homing. ltbr is essential for the differentiation and homeostasis of these thymic portal ecs. finally, we show that ltbr is required for t-cell regeneration on irradiation-induced thymic injury. together, these results uncover a cellular and molecular pathway that governs thymic ec differentiation for hpc homing.
WOS关键词	EPITHELIAL-CELLS ; DENDRITIC CELLS ; LYMPH-NODE ; LYMPHOTOXIN PATHWAY ; CENTRAL TOLERANCE ; ADULT THYMUS ; RECEPTOR ; TRANSPLANTATION ; MIGRATION ; RECONSTITUTION
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000380860200001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374472
专题	中国科学院大学
通讯作者	Zhu, Mingzhao
作者单位	1.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Coll Life Sci, Biodynam Opt Imaging Ctr, Beijing 100871, Peoples R China 4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China 5.UT Southwestern Med Ctr, Dept Pathol & Immunol, Dallas, TX 75235 USA
推荐引用方式 GB/T 7714	Shi, Yaoyao,Wu, Weiwei,Chai, Qian,et al. Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration[J]. Nature communications,2016,7:12.
APA	Shi, Yaoyao.,Wu, Weiwei.,Chai, Qian.,Li, Qingqing.,Hou, Yu.,...&Zhu, Mingzhao.(2016).Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration.Nature communications,7,12.
MLA	Shi, Yaoyao,et al."Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration".Nature communications 7(2016):12.

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