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	Complete nucleotide sequence of ph11, an inchi2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical klebsiella pneumoniae isolate
	Zhai, Yao1; He, Zilong2,3; Kang, Yu2; Yu, Haiying2; Wang, Jianfeng4; Du, Pengcheng5; Zhang, Zhao1; Hu, Songnian2; Gao, Zhancheng1
刊名	Plasmid
	2016-07-01
卷号	86页码:26-31
关键词	Klebsiella pneumoniae plasmid Complete sequence Multi-antibiotic resistance Multi-heavy metal resistance
ISSN号	0147-619X
DOI	10.1016/j.plasmid.2016.04.001
通讯作者	Hu, songnian(husn@big.ac.cn) ; Gao, zhancheng(zcgao@bjmu.edu.cn)
英文摘要	The complete 284,628 bp sequence of ph11, an inchi2 plasmid, was determined through single-molecule, real-time (smrt) sequencing. harbored by a clinical klebsiella pneumoniae strain h11, and isolated in beijing, this plasmid contains multiple antibiotic resistance genes, including cata2, aac(6')-ib, strb, stra, dfra19, bla(tem-1), sul1, qace delta 1, erea, arr2, and aac3. the aac(6')-ib is carried by a class i integron. plasmid ph11 also carries several genes associated with resistance to heavy metals, such as tellurium, mercury, cobalt, zinc, nickel, copper, lead and cadmium. this plasmid exhibits numerous characteristics, including hipba and relbe toxin-antitoxin systems, two major transfer (tra) regions closely related to those of salmonella enterica serovar plasmid prh-r27, a type ii restriction modification system (ecorii r-m system), several methyltransferases and methylases and genes encoding hha and stpa. these characteristics suggest that ph11 may adapt to various hosts and environments. multiple insertion sequence elements, transposases, recombinases, resolvases and integrases are scattered throughout ph11. the presence of these genes may indicate that horizontal gene transfer occurs frequently in ph11 and thus may facilitate the dissemination of antimicrobial resistance determinants. our data suggest that ph11 is a chimera gradually assembled through the integration of different horizontally acquired dna segments via transposition or homologous recombination. (c) 2016 elsevier inc. all rights reserved.
WOS关键词	TOXIN-ANTITOXIN SYSTEMS ; SPECTRUM BETA-LACTAMASE ; ESCHERICHIA-COLI ; PSEUDOMONAS-AERUGINOSA ; MUTATIONAL ANALYSIS ; R27 ; PROKARYOTES ; INHIBITION ; TELLURITE ; PROTEINS
WOS研究方向	Genetics & Heredity ; Microbiology
WOS类目	Genetics & Heredity ; Microbiology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000380579100004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374459
专题	中国科学院大学
通讯作者	Hu, Songnian; Gao, Zhancheng
作者单位	1.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Beijing Inst Genom, Core Genom Facil, Beijing 100101, Peoples R China 5.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100015, Peoples R China
推荐引用方式 GB/T 7714	Zhai, Yao,He, Zilong,Kang, Yu,et al. Complete nucleotide sequence of ph11, an inchi2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical klebsiella pneumoniae isolate[J]. Plasmid,2016,86:26-31.
APA	Zhai, Yao.,He, Zilong.,Kang, Yu.,Yu, Haiying.,Wang, Jianfeng.,...&Gao, Zhancheng.(2016).Complete nucleotide sequence of ph11, an inchi2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical klebsiella pneumoniae isolate.Plasmid,86,26-31.
MLA	Zhai, Yao,et al."Complete nucleotide sequence of ph11, an inchi2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical klebsiella pneumoniae isolate".Plasmid 86(2016):26-31.

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