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	Near-infrared ag2s quantum dots-based dna logic gate platform for mirna diagnostics
	Miao, Peng1,2; Tang, Yuguo1,2; Wang, Bidou1; Meng, Fanyu1
刊名	Analytical chemistry
	2016-08-02
卷号	88期号:15页码:7567-7573
ISSN号	0003-2700
DOI	10.1021/acs.analchem.6b01044
通讯作者	Miao, peng(miaopeng@sibet.ac.cn) ; Tang, yuguo(tangyg@sibet.ac.cn)
英文摘要	Dysregulation of mirna expression is correlated with the development and progression of many diseases. these mirnas are regarded as promising biomarkers. however, it is challenging to measure these low abundant molecules without employing time-consuming radioactive labeling or complex amplification strategies. here, we present a dna logic gate platform for mirna diagnostics with fluorescence outputs from near-infrared (nir) ag2s quantum dots (qds). carefully designed toehold exchange-mediated strand displacements with different mirna inputs occur on a solid-state interface, which control qds release from solid-state interface to solution, responding to multiplex information on initial mirnas. excellent fluorescence emission properties of nir ag2s qds certify the great prospect for amplification-free and sensitive mirna assay. we demonstrate the potential of this platform by achieving femtomolar level mirna analysis and the versatility of a series of logic circuits computation.
WOS关键词	HYBRIDIZATION CHAIN-REACTION ; ROLLING CIRCLE AMPLIFICATION ; MICRORNA EXPRESSION ; SIGNAL AMPLIFICATION ; ISOTHERMAL AMPLIFICATION ; ULTRASENSITIVE DETECTION ; SENSITIVE DETECTION ; CANCER ; ASSAY ; SPECIFICITY
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000380967800021
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374432
专题	中国科学院大学
通讯作者	Miao, Peng; Tang, Yuguo
作者单位	1.Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Miao, Peng,Tang, Yuguo,Wang, Bidou,et al. Near-infrared ag2s quantum dots-based dna logic gate platform for mirna diagnostics[J]. Analytical chemistry,2016,88(15):7567-7573.
APA	Miao, Peng,Tang, Yuguo,Wang, Bidou,&Meng, Fanyu.(2016).Near-infrared ag2s quantum dots-based dna logic gate platform for mirna diagnostics.Analytical chemistry,88(15),7567-7573.
MLA	Miao, Peng,et al."Near-infrared ag2s quantum dots-based dna logic gate platform for mirna diagnostics".Analytical chemistry 88.15(2016):7567-7573.

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