| Neprilysin confers genetic susceptibility to alzheimer's disease in han chinese | |
| Wang, Hui-Zhen1; Bi, Rui1; Zhang, Deng-Feng1,2; Li, Guo-Dong1,2; Ma, Xiao-Hong3,4; Fang, Yiru5; Li, Tao3,4; Zhang, Chen5; Yao, Yong-Gang1,2,6 | |
| 刊名 | Molecular neurobiology
 |
| 2016-09-01 | |
| 卷号 | 53期号:7页码:4883-4892 |
| 关键词 | Alzheimer's disease Neprilysin A beta-degrading enzyme Chinese Genetic susceptibility |
| ISSN号 | 0893-7648 |
| DOI | 10.1007/s12035-015-9411-z |
| 通讯作者 | Yao, yong-gang(yaoyg@mail.kiz.ac.cn) |
| 英文摘要 | Alzheimer's disease (ad) is a progressive neurodegenerative disease, with increasing incidence all over the world. amyloid-beta (a beta) was considered to be the original cause to ad, and many reported pathogenic or risk genes for ad were located in the a beta generation and degradation pathways. neprilysin (nep), insulin-degrading enzyme (ide), and matrix metalloprotease-9 (mmp-9) are the most important a beta-degrading proteases. accumulating genetic evidence suggested that single nucleotide polymorphisms (snps) of these genes confer susceptibility to ad in caucasian populations. in this study, we screened eight snps within these three a beta-degrading protease genes in 1475 individuals of two independent han chinese case-control cohorts. snp rs1816558 of nep was found to be significantly associated with ad after adjustment for epsilon 4 allele of the apolipoprotein e gene (apoe epsilon 4) and the bonferroni correction. the remaining variants were not associated with risk of ad in han chinese sample set. further data mining revealed that messenger rna (mrna) level of nep substantially increased during the development of ad and was positively correlated with app expression. the combined results indicated that nep confers genetic susceptibility to ad in han chinese populations. |
| WOS关键词 | INSULIN-DEGRADING ENZYME ; CEREBRAL AMYLOID ANGIOPATHY ; BLOCK SPANNING IDE ; NO ASSOCIATION ; A-BETA ; APOLIPOPROTEIN-E ; COMMON VARIANTS ; ONSET ; RISK ; BRAIN |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| 出版者 | HUMANA PRESS INC |
| WOS记录号 | WOS:000380678600048 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2374429 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yao, Yong-Gang |
| 作者单位 | 1.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 3.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610064, Sichuan, Peoples R China 4.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu 610064, Sichuan, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai 200030, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui-Zhen,Bi, Rui,Zhang, Deng-Feng,et al. Neprilysin confers genetic susceptibility to alzheimer's disease in han chinese[J]. Molecular neurobiology,2016,53(7):4883-4892. |
| APA | Wang, Hui-Zhen.,Bi, Rui.,Zhang, Deng-Feng.,Li, Guo-Dong.,Ma, Xiao-Hong.,...&Yao, Yong-Gang.(2016).Neprilysin confers genetic susceptibility to alzheimer's disease in han chinese.Molecular neurobiology,53(7),4883-4892. |
| MLA | Wang, Hui-Zhen,et al."Neprilysin confers genetic susceptibility to alzheimer's disease in han chinese".Molecular neurobiology 53.7(2016):4883-4892. |
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