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	Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation
	Liu, Zhaoting1; Ning, Guozhu1; Xu, Ranran1; Cao, Yu1; Meng, Anming2; Wang, Qiang1,3
刊名	Nature communications
	2016-08-01
卷号	7页码:15
ISSN号	2041-1723
DOI	10.1038/ncomms12603
通讯作者	Meng, anming(mengam@mail.tsinghua.edu.cn) ; Wang, qiang(qiangwang@ioz.ac.cn)
英文摘要	Microtubules function in tgf-beta signalling by facilitating the cytoplasmic trafficking of internalized receptors and the nucleocytoplasmic shuttling of smads. however, nothing is known about whether actin filaments are required for these processes. here we report that zebrafish actin-bundling protein fscn1a is highly expressed in mesendodermal precursors and its expression is directly regulated by the tgf-beta superfamily member nodal. knockdown or knockout of fscn1a leads to a reduction of nodal signal transduction and endoderm formation in zebrafish embryos. fscn1 specifically interacts with tgf-beta family type i receptors, and its depletion disrupts the association between receptors and actin filaments and sequesters the internalized receptors into clathrin-coated vesicles. therefore, fscn1 acts as a molecular linker between tgf-beta family type i receptors and the actin filaments to promote the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes during zebrafish endoderm formation.
WOS关键词	CLATHRIN-MEDIATED ENDOCYTOSIS ; INHIBITS MESODERM INDUCTION ; ACTIN BUNDLE FORMATION ; INTERNALIZATION STEP ; CELL MIGRATION ; COATED PITS ; ZEBRAFISH ; FASCIN ; CYTOSKELETON ; EXPRESSION
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000381905600001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374420
专题	中国科学院大学
通讯作者	Meng, Anming; Wang, Qiang
作者单位	1.Chinese Acad Sci, Inst Zool, CAS Ctr Excellence Mol Cell Sci, State Key Lab Membrane Biol, Beijing 100101, Peoples R China 2.Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhaoting,Ning, Guozhu,Xu, Ranran,et al. Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation[J]. Nature communications,2016,7:15.
APA	Liu, Zhaoting,Ning, Guozhu,Xu, Ranran,Cao, Yu,Meng, Anming,&Wang, Qiang.(2016).Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation.Nature communications,7,15.
MLA	Liu, Zhaoting,et al."Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation".Nature communications 7(2016):15.

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