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	Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis
	Wang, Yanqun1; Liu, Di2,3; Shi, Weifeng4; Lu, Roujian1; Wang, Wenling1; Zhao, Yanjie1; Deng, Yao1; Zhou, Weimin1; Ren, Hongguang5; Wu, Jun
刊名	Mbio
	2015-09-01
卷号	6期号:5页码:6
ISSN号	2150-7511
DOI	10.1128/mbio.01280-15
通讯作者	Gao, george f.(gaofu@chinacdc.cn)
英文摘要	The middle east respiratory syndrome coronavirus (mers-cov) causes a severe acute respiratory tract infection with a high fatality rate in humans. coronaviruses are capable of infecting multiple species and can evolve rapidly through recombination events. here, we report the complete genomic sequence analysis of a mers-cov strain imported to china from south korea. the imported virus, provisionally named chinagdoi, belongs to group 3 in clade b in the whole-genome phylogenetic tree and also has a similar tree topology structure in the open reading frame la and -b (orflab) gene segment but clusters with group 5 of clade b in the tree constructed using the s gene. genetic recombination analysis and lineage-specific single-nucleotide polymorphism (snp) comparison suggest that the imported virus is a recombinant comprising group 3 and group 5 elements. the time-resolved phylogenetic estimation indicates that the recombination event likely occurred in the second half of 2014. genetic recombination events between group 3 and group 5 of clade b may have implications for the transmissibility of the virus. importance the recent outbreak of mers-cov in south korea has attracted global media attention due to the speed of spread and onward transmission. here, we present the complete genome of the first imported mers-cov case in china and demonstrate genetic recombination events between group 3 and group 5 of clade b that may have implications for the transmissibility of mers-cov.
WOS关键词	SAUDI-ARABIA ; TRANSMISSION ; CAMELS
WOS研究方向	Microbiology
WOS类目	Microbiology
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000364523100030
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374161
专题	计算机网络信息中心
通讯作者	Gao, George F.
作者单位	1.Chinese Ctr Dis Control & Prevent, Key Lab Med Virol, Minist Hlth, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing, Peoples R China 4.Taishan Med Coll, Inst Pathogen Biol, Tai An, Shandong, Peoples R China 5.State Key Lab Pathogen & Biosecur, Beijing, Peoples R China 6.Chinese Ctr Dis Control & Prevent, Off Director Gen, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yanqun,Liu, Di,Shi, Weifeng,et al. Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis[J]. Mbio,2015,6(5):6.
APA	Wang, Yanqun.,Liu, Di.,Shi, Weifeng.,Lu, Roujian.,Wang, Wenling.,...&Tan, Wenjie.(2015).Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis.Mbio,6(5),6.
MLA	Wang, Yanqun,et al."Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis".Mbio 6.5(2015):6.

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