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	Crystal structure of the swine-origin a (h1n1)-2009 influenza a virus hemagglutinin (ha) reveals similar antigenicity to that of the 1918 pandemic virus
	Zhang, Wei1,2; Qi, Jianxun1; Shi, Yi1,2; Li, Qing1,2,3; Gao, Feng4; Sun, Yeping1; Lu, Xishan1,5; Lu, Qiong1,2; Vavricka, Christopher J.1; Liu, Di1,6
刊名	Protein & cell
	2010-05-01
卷号	1期号:5页码:459-467
关键词	Influenza virus Pandemic 2009 1918 S-oiv Hemagglutinin (ha) Structure
ISSN号	1674-800X
DOI	10.1007/s13238-010-0059-1
通讯作者	Gao, george f.(gaof@im.ac.cn)
英文摘要	Influenza virus is the causative agent of the seasonal and occasional pandemic flu. the current h1n1 influenza pandemic, announced by the who in june 2009, is highly contagious and responsible for global economic losses and fatalities. although the h1n1 gene segments have three origins in terms of host species, the virus has been named swine-origin influenza virus (s-oiv) due to a predominant swine origin. 2009 s-oiv has been shown to highly resemble the 1918 pandemic virus in many aspects. hemagglutinin is responsible for the host range and receptor binding of the virus and is therefore a primary indicator for the potential of infection. primary sequence analysis of the 2009 s-oiv hemagglutinin (ha) reveals its closest relationship to that of the 1918 pandemic influenza virus, however, analysis at the structural level is necessary to critically assess the functional significance. in this report, we report the crystal structure of soluble hemagglutinin h1 (09h1) at 2.9 angstrom, illustrating that the 09h1 is very similar to the 1918 pandemic ha (18h1) in overall structure and the structural modules, including the five defined antiboby (ab)-binding epitopes. our results provide an explanation as to why sera from the survivors of the 1918 pandemics can neutralize the 2009 s-oiv, and people born around the 1918 are resistant to the current pandemic, yet younger generations are more susceptible to the 2009 pandemic.
WOS研究方向	Cell Biology
WOS类目	Cell Biology
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000208510900009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374127
专题	计算机网络信息中心
通讯作者	Gao, George F.
作者单位	1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogenic Microbiol & Immunol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Coll Life Sci, Hefei 230027, Peoples R China 4.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 5.China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China 6.Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wei,Qi, Jianxun,Shi, Yi,et al. Crystal structure of the swine-origin a (h1n1)-2009 influenza a virus hemagglutinin (ha) reveals similar antigenicity to that of the 1918 pandemic virus[J]. Protein & cell,2010,1(5):459-467.
APA	Zhang, Wei.,Qi, Jianxun.,Shi, Yi.,Li, Qing.,Gao, Feng.,...&Gao, George F..(2010).Crystal structure of the swine-origin a (h1n1)-2009 influenza a virus hemagglutinin (ha) reveals similar antigenicity to that of the 1918 pandemic virus.Protein & cell,1(5),459-467.
MLA	Zhang, Wei,et al."Crystal structure of the swine-origin a (h1n1)-2009 influenza a virus hemagglutinin (ha) reveals similar antigenicity to that of the 1918 pandemic virus".Protein & cell 1.5(2010):459-467.

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