| Genetic properties and pathogenicity of a novel reassortant h10n5 influenza virus from wild birds | |
| Jia, Yane1; Yang, Jiayun1; Wang, Zhengxiang1; Du, Yingying1; Cui, Jie2; Wang, Liang1; Guo, Fengfeng1; Yang, Maijuan1; Han, Shufang1; Zhu, Qiyun1 | |
| 刊名 | Archives of virology
 |
| 2017-05-01 | |
| 卷号 | 162期号:5页码:1349-1353 |
| 关键词 | Avian influenza virus H10n5 Reassortant Mouse-adapted |
| ISSN号 | 0304-8608 |
| DOI | 10.1007/s00705-017-3234-3 |
| 通讯作者 | Zhu, qiyun(zhuqiyun@caas.cn) |
| 英文摘要 | In this study, we analyzed the genome of a h10n5 influenza virus from wild birds. this virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. after sequential passage in mice, mouse-adapted viruses bearing mutations pb2-e627k and ha-g218e were generated. these viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic h10n5 in chickens can be enhanced after passage in mammals. our data imply that h10n5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses. |
| WOS关键词 | RECEPTOR-BINDING ; A VIRUS ; MOLECULAR-BASIS ; MICE ; VIRULENCE ; CHINA ; CHICKENS ; POULTRY ; MINK ; SUBSTITUTION |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | SPRINGER WIEN |
| WOS记录号 | WOS:000399200000020 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2373443 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, Qiyun |
| 作者单位 | 1.CAAS, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, 1 Xujiaping, Lanzhou 730046, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Yane,Yang, Jiayun,Wang, Zhengxiang,et al. Genetic properties and pathogenicity of a novel reassortant h10n5 influenza virus from wild birds[J]. Archives of virology,2017,162(5):1349-1353. |
| APA | Jia, Yane.,Yang, Jiayun.,Wang, Zhengxiang.,Du, Yingying.,Cui, Jie.,...&Zhu, Qiyun.(2017).Genetic properties and pathogenicity of a novel reassortant h10n5 influenza virus from wild birds.Archives of virology,162(5),1349-1353. |
| MLA | Jia, Yane,et al."Genetic properties and pathogenicity of a novel reassortant h10n5 influenza virus from wild birds".Archives of virology 162.5(2017):1349-1353. |
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