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	Molecular evolution and emergence of h5n6 avian influenza virus in central china
	Du, Yingying1; Chen, Mingyue1; Yang, Jiayun1; Jia, Yane1; Han, Shufang1; Holmes, Edward C.2,3; Cui, Jie1
刊名	Journal of virology
	2017-06-01
卷号	91期号:12页码:8
关键词	H5n6 Avian influenza virus Evolution Molecular epidemiology Reassortment
ISSN号	0022-538X
DOI	10.1128/jvi.00143-17
通讯作者	Cui, jie(jiecui@wh.iov.cn)
英文摘要	H5n6 avian influenza virus (aiv) has posed a potential threat to public health since its emergence in china in 2013. to understand the evolution and emergence of h5n6 aiv in the avian population, we performed molecular surveillance of live poultry markets (lpms) in wugang prefecture, hunan province, in central china, during 2014 and 2015. wugang prefecture is located on the eastern asian-australian migratory bird flyway, and a human death due to an h5n6 virus was reported in the prefecture on 21 november 2016. in total, we sampled and sequenced the complete genomes of 175 h5n6 aivs. notably, our analysis revealed that h5n6 aivs contain at least six genotypes arising from segment reassortment, including a rare variant that possesses an ha gene derived from h5n1 clade 2.3.2 and a novel np gene that has its origins with h7n3 viruses. in addition, phylogenetic analysis revealed that genetically similar h5n6 aivs tend to cluster according to their geographic regions of origin. these results help to reveal the evolutionary behavior of influenza viruses prior to their emergence in humans. importance the newly emerged h5n6 influenza a virus has caused more than 10 human deaths in china since 2013. in november 2016, a human death due to an h5n6 virus, in wugang prefecture, hunan province, was confirmed by the who. to better understand the evolution and emergence of h5n6 viruses, we surveyed live poultry markets (lpms) in wugang prefecture before the reported human death, with a focus on revealing the diversity and genomic origins of h5n6 in birds during 2014 and 2015. in general, h5n6 viruses in this region were most closely related to h5n1 clade 2.3.4.4, with the exception of one virus with an ha gene derived from clade 2.3.2 such that it represents a novel reassortant. clearly, the ongoing surveillance of lpms is central to monitoring the emergence of pathogenic influenza viruses.
WOS关键词	MAXIMUM-LIKELIHOOD PHYLOGENIES ; REASSORTANT ; INFECTION ; GENESIS ; PHYML
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000402169500006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373424
专题	武汉病毒研究所
通讯作者	Cui, Jie
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China 2.Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sch Life & Environm Sci, Sydney, NSW, Australia 3.Univ Sydney, Sydney Med Sch, Charles Perkins Ctr, Sydney, NSW, Australia
推荐引用方式 GB/T 7714	Du, Yingying,Chen, Mingyue,Yang, Jiayun,et al. Molecular evolution and emergence of h5n6 avian influenza virus in central china[J]. Journal of virology,2017,91(12):8.
APA	Du, Yingying.,Chen, Mingyue.,Yang, Jiayun.,Jia, Yane.,Han, Shufang.,...&Cui, Jie.(2017).Molecular evolution and emergence of h5n6 avian influenza virus in central china.Journal of virology,91(12),8.
MLA	Du, Yingying,et al."Molecular evolution and emergence of h5n6 avian influenza virus in central china".Journal of virology 91.12(2017):8.

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