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	Two reassortant types of highly pathogenic h5n8 avian influenza virus from wild birds in central china in 2016
	Ma, Liping1,2,3; Jin, Tao4; Wang, Hanzhong1; Liu, Haizhou1; Wang, Runkun1; Li, Yong5; Yang, Guoxiang5; Xiong, Yanping5; Chen, Jing5; Zhang, Jun5
刊名	Emerging microbes & infections
	2018-02-07
卷号	7页码:8
ISSN号	2222-1751
DOI	10.1038/s41426-017-0012-y
通讯作者	Chen, quanjiao(chenqj@wh.iov.cn)
英文摘要	Since 2016, the highly pathogenic avian influenza h5n8 virus has emerged in the central asian flyway and europe, causing massive deaths in poultry and wild birds. in this study, we isolated and identified three h5n8 viruses from swan goose and black swans in hubei province during the 2016/2017 winter season. whole-genome sequencing and phylogenetic analysis revealed that the three viruses clustered into a group of h5n8 viruses from qinghai lake and europe. a novel reassortment virus from swan goose was distinguished from that of black swans, in that its pa and np genes were distinct from those of qinghai lake viruses. molecular dating revealed that the ancestral strain of these h5n8 viruses emerged around july 2015. from sequence comparison, we discovered eight amino acid substitutions in ha and na during the adaption process from poultry to wild birds. the three viruses were isolated from wild birds in the east asian-australasian flyway; however, the viral genomes were similar to h5n8 viruses circulating along the central asian flyway. from these data, we conclude that wetlands and lakes in central china may play a key role in disseminating h5n8 viruses between the east asian-australasian and central asian flyways.
WOS关键词	RECEPTOR SPECIFICITY ; A(H5N8) VIRUSES ; HEMAGGLUTININ ; RESISTANCE ; EVOLUTION ; POULTRY ; DUCKS
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000425547800006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373311
专题	武汉病毒研究所
通讯作者	Chen, Quanjiao
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.BGI Shenzhen, China Natl Genebank Shenzhen, Shenzhen 518120, Peoples R China 5.Monitoring Ctr Wildlife Dis & Resource Hubei, Wuhan 430071, Hubei, Peoples R China 6.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China 7.ChineseCtr Dis Control & Prevent China CDC, Off Director Gen, Beijing 102206, Peoples R China
推荐引用方式 GB/T 7714	Ma, Liping,Jin, Tao,Wang, Hanzhong,et al. Two reassortant types of highly pathogenic h5n8 avian influenza virus from wild birds in central china in 2016[J]. Emerging microbes & infections,2018,7:8.
APA	Ma, Liping.,Jin, Tao.,Wang, Hanzhong.,Liu, Haizhou.,Wang, Runkun.,...&Chen, Quanjiao.(2018).Two reassortant types of highly pathogenic h5n8 avian influenza virus from wild birds in central china in 2016.Emerging microbes & infections,7,8.
MLA	Ma, Liping,et al."Two reassortant types of highly pathogenic h5n8 avian influenza virus from wild birds in central china in 2016".Emerging microbes & infections 7(2018):8.

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