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	Impairments of spatial memory in an alzheimer's disease model via degeneration of hippocampal cholinergic synapses
	Zhu, Houze1,2,3; Yan, Huanhuan1,2,3; Tang, Na1,2,3; Li, Xinyan1,2,3; Pang, Pei1,2,3; Li, Hao1,2,3; Chen, Wenting1,2,3; Guo, Yu1,2,3; Shu, Shu1,2,3; Cai, You1,2,3
刊名	Nature communications
	2017-11-22
卷号	8页码:13
ISSN号	2041-1723
DOI	10.1038/s41467-017-01943-0
通讯作者	Mu, yangling(ymu@hust.edu.cn) ; Zhu, ling-qiang(zhulq@hust.edu.cn) ; Lu, youming(lym@hust.edu.cn)
英文摘要	Choline acetyltransferase neurons in the vertical diagonal band of broca (vchats) degenerate in the early stage of alzheimer's disease (ad). here, we report that vchats directly innervate newly generated immature neurons (ngis) in the dorsal hippocampus (dngis) of adult mice and regulate both the dngis survival and spatial pattern separation. in a mouse model that exhibits amyloid-beta plaques similar to ad patients, cholinergic synaptic transmission, dngi survival and spatial pattern separation are impaired. activation of vchats with theta burst stimulation (tbs) that alleviates the decay in cholinergic synaptic transmission effectively protects against spatial pattern separation impairments in the ad mice and this protection was completely abolished by inhibiting the dngis survival. thus, the impairments of pattern separation-associated spatial memory in ad mice are in part caused by degeneration of cholinergic synaptic transmission that modulates the dngis survival.
WOS关键词	DEEP BRAIN-STIMULATION ; SYNAPTIC PLASTICITY ; ADULT NEUROGENESIS ; MOUSE MODELS ; TRANSGENIC MICE ; NEURAL CIRCUITS ; DENTATE GYRUS ; A-BETA ; ACETYLCHOLINE ; NEURONS
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000416226200005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373303
专题	武汉病毒研究所
通讯作者	Mu, Yangling; Zhu, Ling-Qiang; Lu, Youming
作者单位	1.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Physiol, Wuhan 4030030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 4030030, Hubei, Peoples R China 3.Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Inst Brain Res, Wuhan 430030, Hubei, Peoples R China 4.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Neurobiol, Wuhan 4030030, Hubei, Peoples R China 5.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Genet, Wuhan 4030030, Hubei, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Virol, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 7.Boston Univ, Dept Biol, 5 Cummington St, Boston, MA 02215 USA 8.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathophysiol, Wuhan 430030, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Houze,Yan, Huanhuan,Tang, Na,et al. Impairments of spatial memory in an alzheimer's disease model via degeneration of hippocampal cholinergic synapses[J]. Nature communications,2017,8:13.
APA	Zhu, Houze.,Yan, Huanhuan.,Tang, Na.,Li, Xinyan.,Pang, Pei.,...&Lu, Youming.(2017).Impairments of spatial memory in an alzheimer's disease model via degeneration of hippocampal cholinergic synapses.Nature communications,8,13.
MLA	Zhu, Houze,et al."Impairments of spatial memory in an alzheimer's disease model via degeneration of hippocampal cholinergic synapses".Nature communications 8(2017):13.

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