QQ客服 官方微博 反馈留言

	A 3d human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier
	Yin, Fangchao1,4; Zhu, Yujuan1,4; Zhang, Min1; Yu, Hao1; Chen, Wenwen1,4; Qin, Jianhua1,2,3,4
刊名	Toxicology in vitro
	2019-02-01
卷号	54页码:105-113
关键词	3d human placenta-on-a-chip Nanoparticle exposure Organ-on-a -chip
ISSN号	0887-2333
DOI	10.1016/j.tiv.2018.08.014
通讯作者	Qin, jianhua(jhqin@dicp.ac.cn)
英文摘要	With the commercialization of nanomaterials, environmental exposure to nanoparticles (nps) has raised great concerns due to the long-term effects to human body, particularly to pregnant women. previous studies found that nps had an adverse impact on placenta in mice, but care must be taken when extrapolating the results to human pregnancy in consideration of the great difference between species. here, we proposed a micro engineered 3d placental barrier-on-a-chip microdevice and further explored complicated placental responses to nps exposure in vitro. the microdevice recreated near-physiological 3d microenvironment and dynamic conditions in fetal maternal circulation combined with the extracellular matrix and flow. with the exposure to titanium dioxide nanoparticles (tio2-nps), a common nanomaterial, a series of placental responses were investigated, including oxidative stress, cell apoptosis, barrier permeability, and maternal immune cell behavior. by contrast to oxidative stress and cell apoptosis, placental barrier integrity and maternal immune cells were greatly influenced even with low concentrated nps, suggesting the potential damages triggered by nps in our daily life. collectively, this in vitro experimental model of human placenta provides a simple platform to study environmental exposure to nps, and might be potential for a wide range of applications in biological study, disease treatment and drug assessment.
WOS关键词	INFLAMMATION
WOS研究方向	Toxicology
WOS类目	Toxicology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000454467300012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2372915
专题	大连化学物理研究所
通讯作者	Qin, Jianhua
作者单位	1.Chinese Acad Sci, Div Biotechnol, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100864, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yin, Fangchao,Zhu, Yujuan,Zhang, Min,et al. A 3d human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier[J]. Toxicology in vitro,2019,54:105-113.
APA	Yin, Fangchao,Zhu, Yujuan,Zhang, Min,Yu, Hao,Chen, Wenwen,&Qin, Jianhua.(2019).A 3d human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier.Toxicology in vitro,54,105-113.
MLA	Yin, Fangchao,et al."A 3d human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier".Toxicology in vitro 54(2019):105-113.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。