Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus)

doi:10.1016/j.aquaculture.2005.10.030

	Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus)
	Xu, Weihai ; Zhu, Xiaobin ; Wang, Xinting ; Deng, Liping ; Zhang, Gan
刊名	AQUACULTURE
	2006-04-28
卷号	254 期号:1-4 页码:1-8
关键词	Enrofloxacin Furazolidone Metabolite Residues Tilapia (Chinese Shrimp)
ISSN号	0044-8486
DOI	10.1016/j.aquaculture.2005.10.030
文献子类	Article
英文摘要	The residues of enrofloxacin and its metabolite in Nile tilapia (Oreochromis niloticus) were studied after oral dose of 50 mg/kg for 7 days. To find the differences between Nile tilapia and Chinese shrimp (Penaeus chinensis), the residues of enrofloxacin in P chinensis were also studied under the same conditions. The results showed that enrofloxacin metabolized into ciprofloxacin in both Nile tilapia and P chinensis, the maximal concentration of enrofloxacin in muscle, liver and plasma of Nile tilapia were 3.61 mu g/g, 5.96 mu g/g, 1.25 mu g/ml respectively, and ciprofloxacin in muscle was 0.22 mu g/g. The maximal concentration of enrofloxacin and ciprofloxacin in P chinensis were 1.68 mu g/g and 0.07 mu g/g respectively. The predicted withdrawal time for Nile tilapia was 22 days, and P. chinensis was 12 days under our experiment conditions.; The residues of enrofloxacin and its metabolite in Nile tilapia (Oreochromis niloticus) were studied after oral dose of 50 mg/kg for 7 days. To find the differences between Nile tilapia and Chinese shrimp (Penaeus chinensis), the residues of enrofloxacin in P chinensis were also studied under the same conditions. The results showed that enrofloxacin metabolized into ciprofloxacin in both Nile tilapia and P chinensis, the maximal concentration of enrofloxacin in muscle, liver and plasma of Nile tilapia were 3.61 mu g/g, 5.96 mu g/g, 1.25 mu g/ml respectively, and ciprofloxacin in muscle was 0.22 mu g/g. The maximal concentration of enrofloxacin and ciprofloxacin in P chinensis were 1.68 mu g/g and 0.07 mu g/g respectively. The predicted withdrawal time for Nile tilapia was 22 days, and P. chinensis was 12 days under our experiment conditions. The residues of fitrazolidone [3-(5-nitrofurfurylidenamino)-2-oxazolidinone] and its main metabolite 3-amina-2-oxazolidinone (AOZ) in Nile tilapia were first determined by HPLC/MS. Results showed that after oral dose of 30 mg/kg for 7 days, the maximum concentration of farazolidone in Nile tilapia was 413 mu g/kg after 6 h, whereas AOZ residue reached its maximum (31 mu g/kg) right after stopping treatment. In contrast to the high metabolic rate of furazolidone, AOZ was very difficult to eliminate in vivo, thus the withdrawal time of furazolidone in Nile tilapia was 22 days at least. (c) 2005 Elsevier B.V. All rights reserved.
学科主题	Fisheries ; Marine & Freshwater Biology
URL标识	查看原文
语种	英语
WOS记录号	WOS:000237838800001
公开日期	2010-12-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/6169]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Xu, Weihai,Zhu, Xiaobin,Wang, Xinting,et al. Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus)[J]. AQUACULTURE,2006,254(1-4):1-8.
APA	Xu, Weihai,Zhu, Xiaobin,Wang, Xinting,Deng, Liping,&Zhang, Gan.(2006).Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus).AQUACULTURE,254(1-4),1-8.
MLA	Xu, Weihai,et al."Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus)".AQUACULTURE 254.1-4(2006):1-8.