Preparation of 1,3,5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro

doi:10.1016/j.bmcl.2007.05.020

	Preparation of 1,3,5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro
	Ji, Xia ; Zhong, Zhimei ; Chen, Xiaolin ; Xing, Ronge; Liu, Song ; Wang, Lin; Li, Pengcheng
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2007-08-01
卷号	17 期号:15 页码:4275-4279
关键词	Radical Scavenging Effect 1 Reducing Power 3 5-thiadiazine-2-thione Derivatives Of Chitosan
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2007.05.020
文献子类	Article
英文摘要	Three new kinds of 1,3,5-thiadiazine-2-thi one derivatives of chitosan with two different molecular weight (SATTCS1, SATTCS2, TITTCS1, TITTCS2, CITTCS1 and CITTCS2) have been prepared. Their structures were characterized by IR spectroscopy. The substitution degree of derivatives calculated by elemental analyses was 0.47, 0.42, 0.41, 0.38, 0.41 and 0.36, respectively. The result shows that substitution degree of derivatives was higher with lower molecular weight. The antioxidant activity was studied using an established system, such as bydroxyl radical scavenging, superoxide radical scavenging and reducing power. Antioxidant activity of the 1,3,5-thiadiazine-2-thione derivatives of chitosan were stronger than that of chitosans and antioxiclant activity of low molecular weight derivatives were stronger than that of high molecular weight derivatives. It is a potential antioxidant in vitro. (c) 2007 Elsevier Ltd. All rights reserved.; Three new kinds of 1,3,5-thiadiazine-2-thi one derivatives of chitosan with two different molecular weight (SATTCS1, SATTCS2, TITTCS1, TITTCS2, CITTCS1 and CITTCS2) have been prepared. Their structures were characterized by IR spectroscopy. The substitution degree of derivatives calculated by elemental analyses was 0.47, 0.42, 0.41, 0.38, 0.41 and 0.36, respectively. The result shows that substitution degree of derivatives was higher with lower molecular weight. The antioxidant activity was studied using an established system, such as bydroxyl radical scavenging, superoxide radical scavenging and reducing power. Antioxidant activity of the 1,3,5-thiadiazine-2-thione derivatives of chitosan were stronger than that of chitosans and antioxiclant activity of low molecular weight derivatives were stronger than that of high molecular weight derivatives. It is a potential antioxidant in vitro. (c) 2007 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Medicinal ; Chemistry, Organic
URL标识	查看原文
语种	英语
WOS记录号	WOS:000248462300037
公开日期	2010-12-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/6059]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Ji, Xia,Zhong, Zhimei,Chen, Xiaolin,et al. Preparation of 1,3,5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(15):4275-4279.
APA	Ji, Xia.,Zhong, Zhimei.,Chen, Xiaolin.,Xing, Ronge.,Liu, Song.,...&Li, Pengcheng.(2007).Preparation of 1,3,5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(15),4275-4279.
MLA	Ji, Xia,et al."Preparation of 1,3,5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.15(2007):4275-4279.