In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice

doi:10.1016/S1043-6618(03)00103-8

	In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice
	Zhang, QB ; Li, N ; Zhou, GF ; Lu, XL ; Xu, ZH ; Li, Z
刊名	PHARMACOLOGICAL RESEARCH
	2003-08-01
卷号	48 期号:2 页码:151-155
关键词	Porphyra Haitanesis Polysaccharide Aging Lipid Peroxidation
ISSN号	1043-6618
DOI	10.1016/S1043-6618(03)00103-8
文献子类	Article
英文摘要	Sulfated polysaccharide fraction F2 from Porphyra haitanesis (Rhodephyta) showed inhibitory effect on the in vitro lipid peroxidation. In the present study, the age-related changes in the antioxidant enzyme activity, lipid peroxidation, and total antioxidant capacity (TAOC) in different organs in mice were investigated and the in vivo antioxidant effect of F2 in aging mice was checked. Increased endogenous lipid peroxidation and decreased TAOC were observed in aging mice. Intraperitoneal administration of F2 significantly decreased the lipid peroxidation in a dose-dependent manner. F2 treatment increased TAOC and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in all the organs tested in aging mice. It is concluded that the sulfated polysaccharide fraction F2 can be used in compensating the decline in TAOC and the activities of antioxidant enzymes and thereby reduces the risks of lipid peroxidation. (C) 2003 Elsevier Science Ltd. All rights reserved.; Sulfated polysaccharide fraction F2 from Porphyra haitanesis (Rhodephyta) showed inhibitory effect on the in vitro lipid peroxidation. In the present study, the age-related changes in the antioxidant enzyme activity, lipid peroxidation, and total antioxidant capacity (TAOC) in different organs in mice were investigated and the in vivo antioxidant effect of F2 in aging mice was checked. Increased endogenous lipid peroxidation and decreased TAOC were observed in aging mice. Intraperitoneal administration of F2 significantly decreased the lipid peroxidation in a dose-dependent manner. F2 treatment increased TAOC and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in all the organs tested in aging mice. It is concluded that the sulfated polysaccharide fraction F2 can be used in compensating the decline in TAOC and the activities of antioxidant enzymes and thereby reduces the risks of lipid peroxidation. (C) 2003 Elsevier Science Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy
URL标识	查看原文
语种	英语
WOS记录号	WOS:000183923400004
公开日期	2010-12-22
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/3601]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Ocean Univ Qingdao, Coll Chem & Chem Engn, Qingdao 266003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, QB,Li, N,Zhou, GF,et al. In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice[J]. PHARMACOLOGICAL RESEARCH,2003,48(2):151-155.
APA	Zhang, QB,Li, N,Zhou, GF,Lu, XL,Xu, ZH,&Li, Z.(2003).In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice.PHARMACOLOGICAL RESEARCH,48(2),151-155.
MLA	Zhang, QB,et al."In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice".PHARMACOLOGICAL RESEARCH 48.2(2003):151-155.