Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution

	Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution
	Guo, Yong-Xue ; Xiu, Zhi-Long ; Zhang, Dai-Jia ; Wang, Hui ; Wang, Long-Xing ; Xiao, Hong-Bin
刊名	journal of pharmaceutical and biomedical analysis
	2007-03-12
卷号	43 期号:4 页码:1249-1255
关键词	lithospermic acid B kinetics reaction mechanism hydrolysis LC-MS
通讯作者	zhi-long xiu
产权排序	2;5
英文摘要	the degradation of lithospermic acid b (lab) was investigated as a function of buffer concentration, ph and temperature. stability tests were performed using a stability-indicating high-performance liquid chromatography (hplc) with uv-vis detection. the degradation followed pseudo-first-order kinetics under all experimental conditions. the maximum stability of lab was observed at ph 2.0. the log k(ph)-ph profile described by specific acid-base catalysis and water molecules agreed with the experimental results. the overall degradation rate constant as a function of the temperature under the given conditions obeyed the arrhenius equation. the chemical fate of lab in mild acidic solution was investigated, and nine degradation products were detected and tentatively identified by lc-ms analysis. the primary degradation pathway involving the cleavage of ester bond and ring-opened of benzofuran in the lab are proposed. (c) 2006 elsevier b.v. all rights reserved.
WOS标题词	science & technology ; physical sciences ; life sciences & biomedicine
类目[WOS]	chemistry, analytical ; pharmacology & pharmacy
研究领域[WOS]	chemistry ; pharmacology & pharmacy
关键词[WOS]	salvia-miltiorrhiza ; inhibition ; radix ; rats
收录类别	SCI
原文出处	true
语种	英语
WOS记录号	WOS:000245262300008
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/99755]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yong-Xue,Xiu, Zhi-Long,Zhang, Dai-Jia,et al. Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution[J]. journal of pharmaceutical and biomedical analysis,2007,43(4):1249-1255.
APA	Guo, Yong-Xue,Xiu, Zhi-Long,Zhang, Dai-Jia,Wang, Hui,Wang, Long-Xing,&Xiao, Hong-Bin.(2007).Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution.journal of pharmaceutical and biomedical analysis,43(4),1249-1255.
MLA	Guo, Yong-Xue,et al."Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution".journal of pharmaceutical and biomedical analysis 43.4(2007):1249-1255.