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	Determination of Total Arsenic and Arsenic Metabolites in Human Liver Hepatocytes
	Cao Xuan1,2; Yu Jing-Jing2; Wang Geng3; Yu Zhen-Hua2,4; Yang Huang-Hao2; Xu Yuan-Yuan5; Sun Gui-Fan5; Wang Xiao-Ru2
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2009
卷号	37期号:1页码:19-24
关键词	Cell Digestion High Performance Liquid Chromatography-inductively Coupled Plasma-mass Sepetrometry Chang Liver Hepatocytes Arsenic Speciation
ISSN号	0253-3820
文献子类	Article
英文摘要	The effects of direct sampling and three digestion methods were investigated on the determination of arsenic in Chang liver hepatocytes after ultrasonic disintegration were investigated. The results showed that the efficiency of microwave digestion and obturator digestion was better than cold digestion and direct sampling. The day precision (present as RSD) of microwave digestion and obturator digestion were 2.1% and 1.2% the inter-day precision were 1.2% and 2.0%, respectively. The spike recovery for the total As in the sample is 95.7% - 108.1%. The As detection limits with these four sample treatment methods (including direct sampling) were 0.74 - 0.93 mu g/L. In addition, arsenic speciation in Chang liver hepatocytes was also analyzed using the hyphenated technique of high performance liquid chromatography coupled with inductively coupled plasma-mass spectrometry. The experimental results indicated that dimethylarsinic acid (DMA) and an intermediate metabolite of DMA were found lit Chang liver hepatocytes besides inorganic arsenic (As(III) and As(V)).; The effects of direct sampling and three digestion methods were investigated on the determination of arsenic in Chang liver hepatocytes after ultrasonic disintegration were investigated. The results showed that the efficiency of microwave digestion and obturator digestion was better than cold digestion and direct sampling. The day precision (present as RSD) of microwave digestion and obturator digestion were 2.1% and 1.2% the inter-day precision were 1.2% and 2.0%, respectively. The spike recovery for the total As in the sample is 95.7% - 108.1%. The As detection limits with these four sample treatment methods (including direct sampling) were 0.74 - 0.93 mu g/L. In addition, arsenic speciation in Chang liver hepatocytes was also analyzed using the hyphenated technique of high performance liquid chromatography coupled with inductively coupled plasma-mass spectrometry. The experimental results indicated that dimethylarsinic acid (DMA) and an intermediate metabolite of DMA were found lit Chang liver hepatocytes besides inorganic arsenic (As(III) and As(V)).
学科主题	Chemistry, Analytical
语种	英语
WOS记录号	WOS:000265116600004
公开日期	2010-12-22
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/2593]
专题	海洋研究所_海洋生态与环境科学重点实验室
作者单位	1.Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266003, Peoples R China 2.First Inst Oceanog State Ocean Adm, Qingdao 266061, Peoples R China 3.Shandong Univ, Coll Chem & Chem Engn, Jinan 250100, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 5.China Med Univ, Coll Publ Hlth, Shenyang 110001, Peoples R China
推荐引用方式 GB/T 7714	Cao Xuan,Yu Jing-Jing,Wang Geng,et al. Determination of Total Arsenic and Arsenic Metabolites in Human Liver Hepatocytes[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2009,37(1):19-24.
APA	Cao Xuan.,Yu Jing-Jing.,Wang Geng.,Yu Zhen-Hua.,Yang Huang-Hao.,...&Wang Xiao-Ru.(2009).Determination of Total Arsenic and Arsenic Metabolites in Human Liver Hepatocytes.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,37(1),19-24.
MLA	Cao Xuan,et al."Determination of Total Arsenic and Arsenic Metabolites in Human Liver Hepatocytes".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 37.1(2009):19-24.

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