First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes

doi:10.1016/j.vetimm.2016.07.006

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	First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes
	Li, Yi-qun 1,2,3; Zhang, Jian 1,2; Li, Jun 4; Sun, Li 1,2
刊名	VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
	2017-08-01
卷号	190 页码:39-44
关键词	Cd22 Cynoglossus Semilaevis Peripheral Blood Leukocytes Phagocytosis Immune Inhibition
DOI	10.1016/j.vetimm.2016.07.006
文献子类	Article
英文摘要	In mammals, CD22 is a member of the ig superfamily that serves as an inhibitor during B cell responses to foreign antigens. In this study, we characterized for the first time a fish CD22 from tongue sole Cynoglossus semilaevis (CsCD22). CsCD22 possesses the conserved structural features of CD22 and shares 35%-54% sequence identities with other fish CD22. mRNA expression of CsCD22 was most abundant in head kidney and heart. CSCD22 protein was detected on the surface of peripheral blood leukocytes (PBL). In the presence of rCsCD22 antibody, the proliferation, phagocytosis, and antibacterial activity of PBL were significantly increased. These results indicate for the first time that fish CD22 plays an inhibitory role in PBL activation.
语种	英语
WOS记录号	WOS:000408182900006
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/143153]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI USA
推荐引用方式 GB/T 7714	Li, Yi-qun,Zhang, Jian,Li, Jun,et al. First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2017,190:39-44.
APA	Li, Yi-qun,Zhang, Jian,Li, Jun,&Sun, Li.(2017).First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,190,39-44.
MLA	Li, Yi-qun,et al."First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 190(2017):39-44.