Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas | |
Li, Yingxiang1,2,3![]() | |
刊名 | CELL DEATH & DISEASE
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2017-07-01 | |
卷号 | 8 |
DOI | 10.1038/cddis.2017.307 |
文献子类 | Article |
英文摘要 | Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite controversial. In this study, we investigated the molecular mechanism of mitochondrial apoptosis in the Pacific oyster Crassostrea gigas. Notably, we show that most key elements involved in the vertebrate mitochondrial apoptosis pathway - including mitochondrial outer membrane permeabilization, cytochrome c release, and caspase activation - are also present in C. gigas. In contrast, the lack of Bcl-2 homology 3-only subfamily members and apoptotic protease activating factor-1 (APAF-1) protein revealed evolutionary diversity from other phyla. Our results support that mitochondrial apoptosis in animals predates the emergence of vertebrates, but suggest that an unexpectedly diverse mitochondrial apoptosis pathway may exist in invertebrates. In addition, our work provided new clues for an improved understanding of how bivalve acclimate themselves to an inconstant environment. |
语种 | 英语 |
WOS记录号 | WOS:000406870400004 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://ir.qdio.ac.cn/handle/337002/143094] ![]() |
专题 | 海洋研究所_海洋生物技术研发中心 海洋研究所_实验海洋生物学重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Yingxiang,Zhang, Linlin,Qu, Tao,et al. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas[J]. CELL DEATH & DISEASE,2017,8. |
APA | Li, Yingxiang,Zhang, Linlin,Qu, Tao,Tang, Xueying,Li, Li,&Zhang, Guofan.(2017).Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas.CELL DEATH & DISEASE,8. |
MLA | Li, Yingxiang,et al."Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas".CELL DEATH & DISEASE 8(2017). |
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