T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes

doi:10.1021/np8006843

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	T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes
	Ding, Ling 1,2,3; Pfoh, Roland 4; Ruehl, Stephan 4; Qin, Song 2; Laatsch, Hartmut 1; Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
刊名	JOURNAL OF NATURAL PRODUCTS
	2009
卷号	72 期号:1 页码:99-101
ISSN号	0163-3864
DOI	10.1021/np8006843
文献子类	Article
英文摘要	Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC(50) of 6.7 mu g/mL.; Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC50 of 6.7 mu g/mL.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
URL标识	查看原文
语种	英语
WOS记录号	WOS:000262761700018
公开日期	2010-11-18
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/1594]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
作者单位	1.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Univ Gottingen, Dept Inorgan Chem, D-37077 Gottingen, Germany
推荐引用方式 GB/T 7714	Ding, Ling,Pfoh, Roland,Ruehl, Stephan,et al. T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(1):99-101.
APA	Ding, Ling,Pfoh, Roland,Ruehl, Stephan,Qin, Song,Laatsch, Hartmut,&Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.(2009).T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes.JOURNAL OF NATURAL PRODUCTS,72(1),99-101.
MLA	Ding, Ling,et al."T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes".JOURNAL OF NATURAL PRODUCTS 72.1(2009):99-101.