Renoprotective meroterpenoids from the fungus Ganoderma cochlear | |
Wang, Xin-Long2; Wu, Ze-Hong1; Di, Lei2; Zhou, Feng-Jiao2; Yan, Yong-Ming1; Cheng, Yong-Xian1 | |
刊名 | FITOTERAPIA
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2019 | |
卷号 | 132页码:88-93 |
关键词 | Ganoderma cochlear Meroterpenoids ECD calculations Renal fibrosis |
ISSN号 | 0367-326X |
英文摘要 | Nine multifarious new meroterpenoids, cochlearols E-M (1-9), along with seven known meroterpenoids 10-16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6-8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and calculated electronic circular dichroism (ECD). Their biological activities against renal fibrosis were evaluated by using rat normal and diseased renal interstitial fibroblast cells (NRK-49F). The results show that compounds 7a, 7b, and 10a exhibit potent proliferation inhibition in TGF-beta 1-induced NRK-49F cells. |
资助项目 | National Science Fund for Distinguished Young Scholars[81525026] ; NSFC-Joint Foundation of Yunnan Province[U1702287] ; National Natural Science Foundation of China[21472199] |
语种 | 英语 |
资助机构 | National Science Fund for Distinguished Young Scholars ; NSFC-Joint Foundation of Yunnan Province ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/64385] ![]() |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | Cheng, Yong-Xian |
作者单位 | 1.Shenzhen Univ, Hlth Sci Ctr, Sch Med, Guangdong Key Lab Genome Stabil & Dis Prevent,Sch, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,et al. Renoprotective meroterpenoids from the fungus Ganoderma cochlear[J]. FITOTERAPIA,2019,132:88-93. |
APA | Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,Zhou, Feng-Jiao,Yan, Yong-Ming,&Cheng, Yong-Xian.(2019).Renoprotective meroterpenoids from the fungus Ganoderma cochlear.FITOTERAPIA,132,88-93. |
MLA | Wang, Xin-Long,et al."Renoprotective meroterpenoids from the fungus Ganoderma cochlear".FITOTERAPIA 132(2019):88-93. |
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