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	Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205
	Gu, Cheng-Zhen1; Yuan, Sheng-Hao2; Lu, Jing1; Qiao, Yi-Jun3; Song, Yuan-Yuan2; Elzaki, Mohammed Esmail Abdalla2; Yang, Chong-Ren3; Zhang, Ying-Jun3; Zeng, Ren-Sen2
刊名	CHEMISTRY & BIODIVERSITY
	2019
卷号	16期号:1页码:7
关键词	Streptomyces albocycline-type macrolides antibiotic Candida albicans antimicrobial activity biological activity
ISSN号	1612-1872
英文摘要	The actinomycete genus Streptomyces is characterized by producing bioactive secondary metabolites, including antibiotics. In this study, chemical and biological investigations were carried out on Streptomyces strain 4205 isolated from the paddy soil, leading to the identification and characterization of 10 albocycline-type macrolides, among which 4 compounds were new, namely albocyclines A-D (1-4). The structures of 1-10 were identified according to the 1D- and 2D-NMR spectroscopic data. Furthermore, compounds 1-10 were evaluated for antimicrobial activity. Compounds 5-7 displayed antimicrobial activities against Candidaalbicans ATCC 90028 with the same MIC value of 10.0 mg/mL and the IC50 values of 1.5, 1.0, and 1.0 mg/mL, respectively. Thus, the research on Streptomyces sp. is of vital significance for developing new antibiotic agents.
资助项目	Natural Science Foundation of China[31470477] ; Natural Science Foundation of China[31670414] ; Natural Science Foundation of China[31770474] ; Fujian University New Century Talents Support Program[2016-23] ; National Major Agricultural Extension Services Pilot Project ; Fujian Provincial Distinguished Youth Innovative Talent Project ; Fujian-Taiwan Joint Innovative Center for Germplasm Resources and Cultivation of Crop (FJ 2011 Program, China)[2015-75] ; Young and Middle-aged Teachers Education Scientific Research Project of Fujian Provincial Department of Education[JAT170203]
语种	英语
资助机构	Natural Science Foundation of China ; Fujian University New Century Talents Support Program ; National Major Agricultural Extension Services Pilot Project ; Fujian Provincial Distinguished Youth Innovative Talent Project ; Fujian-Taiwan Joint Innovative Center for Germplasm Resources and Cultivation of Crop (FJ 2011 Program, China) ; Young and Middle-aged Teachers Education Scientific Research Project of Fujian Provincial Department of Education
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/64265]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhang, Ying-Jun; Zeng, Ren-Sen
作者单位	1.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Fujian, Peoples R China 2.Fujian Agr & Forestry Univ, Coll Crop Sci, Fuzhou 350002, Fujian, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Gu, Cheng-Zhen,Yuan, Sheng-Hao,Lu, Jing,et al. Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205[J]. CHEMISTRY & BIODIVERSITY,2019,16(1):7.
APA	Gu, Cheng-Zhen.,Yuan, Sheng-Hao.,Lu, Jing.,Qiao, Yi-Jun.,Song, Yuan-Yuan.,...&Zeng, Ren-Sen.(2019).Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205.CHEMISTRY & BIODIVERSITY,16(1),7.
MLA	Gu, Cheng-Zhen,et al."Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205".CHEMISTRY & BIODIVERSITY 16.1(2019):7.

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