Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity

	Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity
	Shang, Ning-Ning; Zhang, Zhouxin; Huang, Jian-Ping; Wang, Li; Luo, Jianying; Yang, Jing; Peng, Teng; Yan, Yijun; Ma, Ya-Tuan; Huang, Sheng-Xiong
刊名	JOURNAL OF ANTIBIOTICS
	2018
卷号	71 期号:7 页码:672-676
ISSN号	0021-8820
英文摘要	Two new glycosylated piericidins, glucopiericidinol A(3) (1) and 7-demethyl-glucopiericidin A (2), along with four known analogs were isolated from the culture broth of Streptomyces sp. KIB-H1083. The chemical structures of new compounds were elucidated by spectroscopic analyses. Their cytotoxicity on HL-60, SMMC-772, A-549, MCF-7, and SW480 cell lines, as well as antimicrobial activities was evaluated. The results showed that glucopiericidin A (4) has potent cytotoxicity against HL-60, SMMC-772, A-549, and MCF-7 cell lines with IC50 values of 0.34, 0.65, 0.60, and 0.50 mu M, respectively. For the antimicrobial activity, piericidin A (6) showed most powerful inhibitory activities against Xanthomonas oryzae pv. oryzicola, and Penicillium decumbens.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/64722]
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Shang, Ning-Ning,Zhang, Zhouxin,Huang, Jian-Ping,et al. Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity[J]. JOURNAL OF ANTIBIOTICS,2018,71(7):672-676.
APA	Shang, Ning-Ning.,Zhang, Zhouxin.,Huang, Jian-Ping.,Wang, Li.,Luo, Jianying.,...&Huang, Sheng-Xiong.(2018).Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity.JOURNAL OF ANTIBIOTICS,71(7),672-676.
MLA	Shang, Ning-Ning,et al."Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity".JOURNAL OF ANTIBIOTICS 71.7(2018):672-676.