SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination | |
Yang, Jiao1; Peng, Hong1; Xie, Xiaoduo1; Hu, Ronggui1,3; Xu, Yumin2 | |
刊名 | AUTOPHAGY
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2018 | |
卷号 | 14期号:6页码:1072-1073 |
ISSN号 | 1554-8627 |
DOI | 10.1080/15548627.2017.1332566 |
文献子类 | Editorial Material |
英文摘要 | The alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect cellular responses in multiple conditions, yet the underlying mechanisms are incompletely understood. We recently reported that the macroautophagy/autophagy receptor SQSTM1/p62, functions as a novel Ub sensor to activate autophagy upon Ub(+) stress (upregulation of the Ub level). First, SQSTM1 was found to undergo extensive ubiquitination and activate autophagy under Ub(+) stress induced by prolonged Bortezomib (BTZ) treatment, Ub overexpression or by heat shock. Mechanistically, Ubiquitination of SQSTM1 disrupts its dimerization of the UBA domain, switching it from an auto-inhibitory conformation to recognize poly-ubiquitinated cargoes, promoting autophagic flux. Interestingly, Ub(+) stress-responsive SQSTM1 ubiquitination is mediated by Ub conjugating enzymes, UBE2D2/3, in a unique E2-dependent manner. Our work has thus revealed a novel mechanism for how SQSTM1 senses cellular Ub stress conditions and regulates selective autophagy in response to diverse intrinsic or extrinsic challenges. |
电子版国际标准刊号 | 1554-8635 |
WOS研究方向 | Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000441263100011 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3470] ![]() |
专题 | 生化所2018年发文 |
通讯作者 | Xie, Xiaoduo; Hu, Ronggui |
作者单位 | 1.CAS Ctr Excellence Mol Cell Sci, Innovat Ctr Cell Signaling Network, Key Lab Syst Biol, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Infect Dis, Sch Med, Shanghai, Peoples R China; 3.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Jiao,Peng, Hong,Xie, Xiaoduo,et al. SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination[J]. AUTOPHAGY,2018,14(6):1072-1073. |
APA | Yang, Jiao,Peng, Hong,Xie, Xiaoduo,Hu, Ronggui,&Xu, Yumin.(2018).SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination.AUTOPHAGY,14(6),1072-1073. |
MLA | Yang, Jiao,et al."SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination".AUTOPHAGY 14.6(2018):1072-1073. |
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