Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells | |
Chen, Xufeng1; Zhao, Jingyao1; Cui, Yu1; Dai, Yuling1; Liu, Haifeng1; Shen, Hao1; Wang, Yuya1; Xing, Huayue1; Zhu, Xiaoyan1; Liu, Xiaolong1 | |
刊名 | NATURE COMMUNICATIONS |
2018 | |
卷号 | 9期号:1页码:3746 |
关键词 | Mediator Med23 Self-renewal Progenitor Cells Differentiation Transcription Expression Activation Subunit Requirement Complex |
ISSN号 | 2041-1723 |
DOI | 10.1038/s41467-018-06282-2 |
文献子类 | Article |
英文摘要 | In response to myeloablative stresses, HSCs are rapidly activated to replenish myeloid progenitors, while maintaining full potential of self-renewal to ensure life-long hematopoiesis. However, the key factors that orchestrate HSC activities during physiological stresses remain largely unknown. Here we report that Med23 controls the myeloid potential of activated HSCs. Ablation of Med23 in hematopoietic system leads to lymphocytopenia. Med23-deficient HSCs undergo myeloid-biased differentiation and lose the self-renewal capacity. Interestingly, Med23-deficient HSCs are much easier to be activated in response to physiological stresses. Mechanistically, Med23 plays essential roles in maintaining stemness genes expression and suppressing myeloid lineage genes expression. Med23 is downregulated in HSCs and Med23 deletion results in better survival under myeloablative stress. Altogether, our findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses. |
WOS研究方向 | Multidisciplinary Sciences |
语种 | 英语 |
WOS记录号 | WOS:000444554800003 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3436] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Liu, Xiaolong; Guo, Fan |
作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai 200031, Peoples R China; 2.Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Dept Obstet & Gynecol, Ctr Translat Med,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Xufeng,Zhao, Jingyao,Cui, Yu,et al. Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells[J]. NATURE COMMUNICATIONS,2018,9(1):3746. |
APA | Chen, Xufeng.,Zhao, Jingyao.,Cui, Yu.,Dai, Yuling.,Liu, Haifeng.,...&Hao, Pei.(2018).Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells.NATURE COMMUNICATIONS,9(1),3746. |
MLA | Chen, Xufeng,et al."Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells".NATURE COMMUNICATIONS 9.1(2018):3746. |
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