Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies

	Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies
	Amy K.Y. Fu; Yu Chen; Nancy Y. Ip
刊名	PHARMACOLOGY & THERAPEUTICS
	2018
文献子类	期刊论文
英文摘要	Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the elderly population, is characterized by progressive cognitive decline and pathological hallmarks of amyloid plaques and neurofibrillary tangles. However, its pathophysiological mechanisms are poorly understood, and diagnostic tools and interventions are limited. Here, we review recent research on the amyloid hypothesis and beta-amyloid–induced dysfunction of neuronal synapses through distinct cell surface receptors. We also review how tau protein leads to synaptotoxicity through pathological modification, localization, and propagation. Finally, we discuss experimental therapeutics for AD and propose potential applications of disease-modifying strategies targeting synaptic failure for improved treatment of AD.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13880]
专题	深圳先进技术研究院_脑所
推荐引用方式 GB/T 7714	Amy K.Y. Fu,Yu Chen,Nancy Y. Ip. Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies[J]. PHARMACOLOGY & THERAPEUTICS,2018.
APA	Amy K.Y. Fu,Yu Chen,&Nancy Y. Ip.(2018).Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies.PHARMACOLOGY & THERAPEUTICS.
MLA	Amy K.Y. Fu,et al."Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies".PHARMACOLOGY & THERAPEUTICS (2018).