Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit

	Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit
	Lei Li; Liping Wang
刊名	Journal of Experimental Neuroscience
	2018
文献子类	期刊论文
英文摘要	Among key survival circuits, defensive response circuits are one of the most intensively studied. A consensus is emerging that multiple, independent circuitries are involved in different conditioned and unconditioned defensive responses. Investigating these well-conserved defensive responses would help us to decipher the basic working mechanism of the brain at a circuitry level and thus shed light on new diagnoses and treatments for neural diseases and disorders. We showed that the visually evoked innate defensive response was modulated by a locus coeruleus-superior colliculus (LC-SC) projection. Our work demonstrates that as conserved and instinctive as the survival circuits are, they are flexible and subject to fine-tuned modulation by experience or internal states of the animals. Here, we provide more data to further discuss the possible downstream mechanisms of the LC-SC pathway for this important modulation of the defensive response, the wide range of flight latency between individual flight responses, and the interpretations of our data with additional statistical analysis.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13877]
专题	深圳先进技术研究院_脑所
推荐引用方式 GB/T 7714	Lei Li,Liping Wang. Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit[J]. Journal of Experimental Neuroscience,2018.
APA	Lei Li,&Liping Wang.(2018).Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit.Journal of Experimental Neuroscience.
MLA	Lei Li,et al."Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit".Journal of Experimental Neuroscience (2018).