Gentle handling attenuates innate defensive responses to visual threats

	Gentle handling attenuates innate defensive responses to visual threats
	Wang Feng; Liu Xuemei; Chen Chen; Liu Yuanming; Wang Zhijie; Huang Kang; Wang Liping
刊名	Frontiers in behavioral neuroscience
	2018
文献子类	期刊论文
英文摘要	Innate defensive responses to threats are essential for animal survival. The complexity and variability of innate defensive behaviors can be due to individual experiences, environmental factors, and internal states. However, it is not completely understood if the gentle handling involved in sensory processing affects innate defensive responses to visual threats. Here, we report attenuation of innate defensive responses after gentle handling accompanied by de-excitation of the intermediate layer (IL) and deep layer (DL) of the superior colliculus (SC) but not of the superficial layer (SL). Our theoretical analysis of the c-Fos network revealed an increased correlation in module 1, which maybe generally functionally associated with fear emotional, a decreased correlation in module 2, which maybe generally functionally associated with sensory processing. The IL of the SC appeared to have the highest correlation with the two modules. We verified the dynamic activities of the IL of SC in response to overhead looming stimulus using fiber photometry. Retrograde labeling of 18 regions of interest (ROIs) showed that the IL received significant inputs from the cortical areas, thalamus, hypothalamus, and brainstem. These data suggest the sensory processing involved in the modulatory roles of the SC in innate fear processing.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13876]
专题	深圳先进技术研究院_脑所
推荐引用方式 GB/T 7714	Wang Feng,Liu Xuemei,Chen Chen,et al. Gentle handling attenuates innate defensive responses to visual threats[J]. Frontiers in behavioral neuroscience,2018.
APA	Wang Feng.,Liu Xuemei.,Chen Chen.,Liu Yuanming.,Wang Zhijie.,...&Wang Liping.(2018).Gentle handling attenuates innate defensive responses to visual threats.Frontiers in behavioral neuroscience.
MLA	Wang Feng,et al."Gentle handling attenuates innate defensive responses to visual threats".Frontiers in behavioral neuroscience (2018).