Evolution of pallium, hippocampus,and cortical cell types revealed by single-cell transcriptomics in reptiles

	Evolution of pallium, hippocampus,and cortical cell types revealed by single-cell transcriptomics in reptiles
	Georgi Tushev; Maria Antonietta Tosches; Tracy M. Yamawaki; Robert K. Naumann; Ariel A. Jacobi; Gilles Laurent
刊名	Science
	2018
文献子类	期刊论文
英文摘要	Computations in the mammalian cortex are carried out by glutamatergic and γ-aminobutyric acid–releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13867]
专题	深圳先进技术研究院_脑所
推荐引用方式 GB/T 7714	Georgi Tushev,Maria Antonietta Tosches,Tracy M. Yamawaki,et al. Evolution of pallium, hippocampus,and cortical cell types revealed by single-cell transcriptomics in reptiles[J]. Science,2018.
APA	Georgi Tushev,Maria Antonietta Tosches,Tracy M. Yamawaki,Robert K. Naumann,Ariel A. Jacobi,&Gilles Laurent.(2018).Evolution of pallium, hippocampus,and cortical cell types revealed by single-cell transcriptomics in reptiles.Science.
MLA	Georgi Tushev,et al."Evolution of pallium, hippocampus,and cortical cell types revealed by single-cell transcriptomics in reptiles".Science (2018).