Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin

	Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin
	Ying-Sui Sun; Chi-Ya Huang; Chiang-Sang Chen; Jean-Heng Chang; Wen-Tao Hou; Shu-Jun Li; Yu-Lin Hao; Haobo Pan; Her-Hsiung Huang
刊名	Surface & Coatings Technology
	2018
文献子类	期刊论文
英文摘要	In this study, we investigated various responses of human bone marrow mesenchymal stem cells (hMSCs) to a low elastic modulus Ti-24Nb-4Zr-8Sn (Ti2448) alloy surface that underwent immobilization using the natural cross-linker genipin. Specifically, hMSC's adhesion, proliferation, mineralization, and differentiation were evaluated. We also analyzed surface characteristics of the Ti2448 alloy, including chemistry, morphology, roughness, and wettability. Our results suggest that genipin immobilized Ti2448 has the potential to benefit orthopedic and dental implant applications. We found that the immobilization of genipin on a sand-blasted/acidetched Ti2448 alloy surface significantly enhanced the mineralization of the extracellular matrix as well as the expression of certain osteogenic markers (bone sialoprotein and osteocalcin) in hMSCs. Conversely, surface roughness and hydrophilicity cannot be credited with the improved cellular responses observed in this study. The immobilization of genipin to produce a biomolecular surface on low elastic modulus Ti2448 alloy has considerable potential for bone implant applications.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14716]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Ying-Sui Sun,Chi-Ya Huang,Chiang-Sang Chen,et al. Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin[J]. Surface & Coatings Technology,2018.
APA	Ying-Sui Sun.,Chi-Ya Huang.,Chiang-Sang Chen.,Jean-Heng Chang.,Wen-Tao Hou.,...&Her-Hsiung Huang.(2018).Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin.Surface & Coatings Technology.
MLA	Ying-Sui Sun,et al."Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin".Surface & Coatings Technology (2018).